Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Thrust back into society after her divorce, Sophia's family issues rise to the surface once more. Unbeknown to Sophia, she is the cause of much unrest in London's criminal underworld. Capturing the interest of mob boss, Markus Falzon, Sophia becomes smitten by his dark and brooding ways. Soon, she will come to realise her true inheritance and her place in London's unlawful society, but a devastating price must be paid...

Winner of the National Book Critics Circle Award and the Man Booker Prize: An “extraordinary” novel “lit by a moral intelligence at once fierce and tender” (The New York Times Book Review). In a crumbling, isolated house at the foot of Mount Kanchenjunga in the Himalayas, an embittered old judge wants only to retire in peace. But his life is upended when his sixteen-year-old orphaned granddaughter, Sai, arrives on his doorstep. The judge’s chatty cook watches over the girl, but his thoughts are mostly with his son, Biju, hopscotching from one miserable New York restaurant job to another, trying to stay a step ahead of the INS. When a Nepalese insurgency threatens Sai’s new-sprung romance with her tutor, the household descends into chaos. The cook witnesses India’s hierarchy being overturned and discarded. The judge revisits his past and his role in Sai and Biju’s intertwining lives. In a grasping world of colliding interests and conflicting desires, every moment holds out the possibility for hope or betrayal. Published to extraordinary acclaim, The Inheritance of Loss heralds Kiran Desai as one of our most insightful novelists. She illuminates the pain of exile and the ambiguities of postcolonialism with a tapestry of colorful characters and “uncannily beautiful” prose (O: The Oprah Magazine). “A book about tradition and modernity, the past and the future—and about the surprising ways both amusing and sorrowful, in which they all connect.” —The Independent

Inheritance is a black sensorium, a chapel of color and sound that speaks to spaciousness, surveillance, identity, desire, and transcendence. Influenced by everyday moments of Washington, DC living, the poems live outside of the outside and beyond the language of categorical difference, inviting anyone listening to listen a bit closer. Inheritance is about the self’s struggle with definition and assumption.

In this book the bestselling author and psychoanalyst Massimo Recalcati offers a fundamental re-examination of what ‘being a mother’ means today, in a world where new social and sexual freedoms mean that motherhood is no longer the sole destiny of women. Questioning the belief that a mother’s love is natural and unconditional, he paints a more complex and troubling picture of the mother–child relationship, observing that mothers may even resent their children as a result of unresolved conflicts between different dimensions of love. The mother’s hands not only nurture but can also potentially harm. Recalcati argues that it is precisely in these competing demands that motherhood fulfils its function: only if the mother is ‘not-all-mother’ can a child experience the absence that enables it to access the symbolic and cultural world. Recalcati cuts through conventional wisdom to offer a fresh perspective on the changing nature of motherhood today. An international bestseller, this book will appeal to a wide general readership, as well as to students and scholars of gender studies, psychoanalysis and related disciplines.

Very little excites human curiosity quite so much as contemplating human origins. More than any other branch of science, evolution - and human evolution in particular - is fraught with controversy. Working from what is essentially the same data, schools of opinion have come to diametrically opposed conclusions. Are we adapted Neanderthals, or a new species altogether which wiped them out? Did the first Americans enter the continent 30,000 or 12,000 years ago? Did the Polynesians sail against wind and current to an unknown fate, or were they just blown across from South America while out fishing? Why do we speak different languages? Is it because language traces our biological history, or are the two things completely unrelated? Evolution, because it deals with a past that can never conclusively be known, was once ideal material for perpetual debate. Enter genetics with a completely new source of objective data. Surely these old questions would soon be settled one way or another. Or would they? Bryan Sykes brings together a world-class set of contributors to debate these questions. The result is eight lively essays, each of which offers a different opinion about what the links between genes, language, and the archaeological record can tell us about human evolution - and indeed, whether they can tell us anything conclusive at all. This stimulating and challenging book poses more questions than it offers answers, eschews jargon, and pursues controversy. Guaranteed to fascinate anyone who has ever wondered how the fossil record, the incredible diversity of human language, and our genetic inheritance might combine to give a glimpse of human origins. Edited by Bryan Sykes, Institute of Molecular Medicine, University of Oxford. Publisher's note.

Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.