This cutting-edge issue of Anesthesiology Clinics is divided into two sections. The first covers topics in perioperative clinical information systems (IS), including the following. The anatomy of an anesthesia information management system; vendor and market landscape; impact of lexicons on adoption of an IS; clinical research using an IS, real-time alerts and reminders using an IS; shortcomings and challenges of IS adoption; creating a real return-on-investment for IS implementation (life after HITECH); Quality improvement using automated data sources and reporting; and opportunities and challenges of implementing an enterprise IS in the OR. Section 2 is devoted to computers and covers the following topics. Advanced integrated real-time clinical displays; enhancing point-of-care vigilance using computers; and computers in perioperative simulation and education.

This issue brings the anesthesiologist up to date on current essential topics in regional analgesia and acute pain management, including the latest state-of-the-art techniques and drugs. Subjects covered include prevention and treatment of local anesthetic systemic and neurotoxicity; complications of RA and pain management (medicolegal issues including anticoagulation, infection, etc.); assessment and treatment of post block neurologic injury (history, physical, investigations, EMG, NCS); new ultrasound guided techniques for peripheral nerve blocks and evidence based outcome review; emerging techniques and drugs for neuraxial and paravertebral blocks; local infiltration analgesia (for a variety of surgical procedures, wound infusions, infusion devices); continuous PNB in hospital and at home; recent advances in multimodal analgesia (new drugs & strategies, such as capsaisin, long acting opioid and local anesthetics); challenges in acute pain management (including the opioid tolerant patient, patients with comorbidities such as MS, DM and renal failure); economics and practice management issues associated with acute pain management; pediatric pain management; new concepts of acute pain management (including strategies to prevent chronic pain, opioid induced hyperalgesia, and more).

This issue of Anesthesiology Clinics provides essential updates in neurosurgical anesthesia. Topics include anesthesia for endovascular neurosurgery; interventional neuroradiology; neuroimaging; anesthetic management of patients with acute stroke; perioperative management of pediatric patients; anesthetic neurotoxicity; airway management in neuroanesthesiology; anesthetic considerations for awake craniotomy for epilepsy; perioperative uses of trans cranial perfusion monitoring; monitoring and introaoperative management of elevated ICP and decompressive craniectomy; electrophysiologic monitoring in neurosurgery; traumatic brain injury; perioperative pain management in the neurosurgical patient; controversies in neurosciences critical care; sleep and mechanisms of anesthesia; and impacts on outcome after neuroanesthesia.

This issue of Anesthesiology Clinics brings the reader up to date on the most important advances in surgical palliative care for anesthesiology intensivists. Topics covered include recent trends and developments, palliative care of patients on high doses of narcotics, trauma in the surgical ICU, care of family in the surgical ICU, communication skills in palliative surgery, surgical palliative care in Haiti, and much more.

This issue on sex and gender comes at an opportune time, as the DSM-IV is being revised, and in particular sex and gender issues are being reconsidered. This issue focuses on research in the area of gender variant children and transgender adolescents, assessment of several scenarios and clear information on practice parameters. Therapy for gender variant children and transgender adolescents is discussed in detail, as well as parents' perspectives, ethical legal, and non-discrimination issues, and education on these subjects. International standards of care are also discussed.

This issue of Anesthesiology Clinics, guest edited by Drs. Gabriella Iohom and Girish P. Joshi, focuses on Perioperative Monitoring. This is one of four issues each year selected by the series consulting editor, Dr. Lee Fleisher. Articles in this issue include, but are not limited to: Clinician monitoring, Ventilation monitoring, Measurement of pulmonary mechanics, Hemodynamic monitoring, Tissue perfusion monitoring, Neuromuscular blockade monitoring, Depth of anesthesia monitoring, Antinociception monitoring, Cerebral perfusion monitoring - Brain oxygen saturation monitoring, Coagulation, Ultrasound - the new stethoscope (POCUS), Mobile and Remote monitoring, smart phone use, AI, machine learning, deep learning, and closed loop devices and Telemedicine for anesthesiologists.

This issue will cover novel approaches to demonstrating value by anesthesiologists. Articles will include Value from the Patient and Payer Perspectives, Perioperative Surgical Home, Demonstrating Value: A British perspective, Demonstrating value: A case study of enhanced recovery, Acute Pain Management/Regional, Measuring Outcomes as Demonstrating Value and many more!