The book introduces the new concepts of target measurement uncertainty and decision rules and explains how to use them to demonstrate a method is fit-for-purpose. As well, they can be used to set the acceptance criteria for a method validation clearly and quantitatively. Examples are given that illustrate the concepts so that the reader can easily apply decision rules and target measurement uncertainty to their methods. The book covers all aspects of method validation from stating the purpose of the method using a Decision Rule, calculating the target measurement uncertainty, deciding the required parameters that need to be included in the method validation, estimating the measurement uncertainty, and setting the acceptance criteria. With this approach the reader will fully understand the method, what its critical control points are and what to control and monitor during routine use. This approach fits in well with the lifecycle approach to analytical methods. The book covers the basics and advanced aspects of method validation so that it is useful for people new to method validation and those with experience. The book is applicable for laboratories in many industries, from mining to pharmaceutical manufacturing to food analysis.

The development of transistors, the integrated circuit, liquid-crystal displays, and even DVD players can be traced back to fundamental research pioneered in the field of condensed-matter and materials physics (CMPP). The United States has been a leader in the field, but that status is now in jeopardy. Condensed-Matter and Materials Physics, part of the Physics 2010 decadal survey project, assesses the present state of the field in the United States, examines possible directions for the 21st century, offers a set of scientific challenges for American researchers to tackle, and makes recommendations for effective spending of federal funds. This book maintains that the field of CMPP is certain to be principle to both scientific and economic advances over the next decade and the lack of an achievable plan would leave the United States behind. This book's discussion of the intellectual and technological challenges of the coming decade centers around six grand challenges concerning energy demand, the physics of life, information technology, nanotechnology, complex phenomena, and behavior far from equilibrium. Policy makers, university administrators, industry research and development executives dependent upon developments in CMPP, and scientists working in the field will find this book of interest.

With the beginning of the twentieth century, American corporations in the chemical and electrical industries began establishing industrial research laboratories. Some went on to become world-famous not only for their scientific and technological breakthroughs but also for the new union of science and industry they represented. Innovative ideas do not simply appear out of the blue and spread on their own merit. Rather, the laboratory's diffusion takes place in a cultural context that goes beyond corporate capital and technological change. Using discourse analysis as a method to comprehensively capture the organizational field of the early American R&D laboratories from 1870 to 1930, this book uncovers the collective meanings associated with the industrial laboratory. Meanings such as what and where a laboratory is supposed to be, who the scientist is, and what it means to practice science provided cultural resources that made the transfer of the laboratory from academic science into an industrial setting possible by rendering such meanings understandable and operable to big business and organizational entrepreneurs fighting for hegemony in a rapidly evolving market. It analyzes not only the corporations that established laboratories in the United States but also their contexts – economic, political, and especially scientific – showing how "the industrial laboratory" was transformed from an organizational novelty into an expected institution in less than two decades. This book will be of interest to researchers, academics, historians, and students in the fields of organizational change, discourse studies, the management of technology and innovation, as well as business and management history.