Immunoregulatory Mechanisms of Interferon
Title | Immunoregulatory Mechanisms of Interferon PDF eBook |
Author | Jorg Hermann Fritz |
Publisher | Frontiers Media SA |
Pages | 362 |
Release | 2020-03-11 |
Genre | |
ISBN | 2889632806 |
Interferons (IFN) belong to the family of cytokines and have been described first in the late 1950s as an inhibitory factor of viral replication. Since then, the impact of interferon has been greatly expanded and its function comprises a role not only in different types of infection, cancer and autoimmunity but importantly also in immunehomeostasis. IFN have important anti-viral effects but it is becoming more and more evident that they are true immunomodulators and have an important impact on the development and maintenance of innate and adaptive immunity.
Molecular Biology of the Cell
Title | Molecular Biology of the Cell PDF eBook |
Author | |
Publisher | |
Pages | 0 |
Release | 2002 |
Genre | Cells |
ISBN | 9780815332183 |
Structures, Signaling Mechanisms, and Functions of Types I and III Interferons
Title | Structures, Signaling Mechanisms, and Functions of Types I and III Interferons PDF eBook |
Author | Ronald L. Rabin |
Publisher | Frontiers Media SA |
Pages | 133 |
Release | 2021-04-23 |
Genre | Medical |
ISBN | 2889666808 |
Dr. Walter receives financial support from Pfizer. The other Topic Editor declares no competing interest with regards to the Research Topic theme.
Interferons
Title | Interferons PDF eBook |
Author | Joe H. Thomas |
Publisher | Nova Science Publishers |
Pages | 0 |
Release | 2012 |
Genre | Interferon |
ISBN | 9781620812983 |
Interferons are cytokines that are very important in regulating both innate and adaptive immune response. Of the two different types of interferons, Type I interferons are potent mediators of the innate immune response against viruses and cancer. Type II interferons, mainly IFN-y enhances T cell polarisation in the lymph nodes that result in their expansion. This book discusses the characterisation, mechanisms of action and clinical applications of interferons. Topics include interferon-gamma, oligodendrocyte injury and inflammatory demyelination; the role of IFN-y in oesophageal squamous cell carcinoma; interferons in multiple sclerosis; the effect of interferons on NK cell activity in HIV infection and tumour cell development; and understanding the mechanisms of interaction between serine proteases, serine protease receptors and interferons.
Interferon-λs: New Regulators of Inflammatory Processes
Title | Interferon-λs: New Regulators of Inflammatory Processes PDF eBook |
Author | Ivan Zanoni |
Publisher | Frontiers Media SA |
Pages | 120 |
Release | 2020-01-14 |
Genre | |
ISBN | 2889633055 |
Indoor Allergens
Title | Indoor Allergens PDF eBook |
Author | National Research Council |
Publisher | National Academies Press |
Pages | 321 |
Release | 1993-02-01 |
Genre | Science |
ISBN | 0309048311 |
More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and schoolâ€"where we spend as much as 98 percent of our time. Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals. Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control. Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, in vitro diagnostic tests, and tests of patients' pulmonary function. This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients.
Immunoregulation
Title | Immunoregulation PDF eBook |
Author | Nicola Fabris |
Publisher | Springer Science & Business Media |
Pages | 473 |
Release | 2012-12-06 |
Genre | Medical |
ISBN | 1468445472 |
Immunoregulation is one of the areas which has witnessed the most explosive advances of immunology during the past decade. It is in this area that the current view of the immune system has arisen and developed. There is indeed little doubt that immune reactions are primarily determined by messages which are genera ted within the immune system and passed among different types of immunologie cells. This cell communication not only determines the type, intensity and duration of the response after perturbation of the immune system by exogenous antigens, but it is also essential for preventing autoimmune reactions and their clinical conse quences. In order to assure aperfect balance within the enormous com plexity of the immune system, it is not surprising that multiple self-regulatory mechanisms are organized at different levels, such as antibody feedback, idiotypic-anti-idiotypic responses, suppres sor and helper T cells, lymphokine signals and genetic require ments. A nu mb er of observations in recent years have, however, demonstrated that consistent contributions to the immunological homeostasis are given also by signals generated outside of the immune system, namely,in the central and autonomous nervous system as weIl as in the endocrine apparatus. Furthermore, the interactions between the immune system and the other body homestatic mechanisms seem to be bidirectional: if immunological cells may be targets of neuroendocrinological factors, immunological products seem in turn to contribute to the neuro endocrine homeostasis.