The rapidly growing field of immunopsychiatry combines expertise and insights from immunology, psychiatry and neuroscience to understand the role of inflammation and other immune processes in causing and treating mental illness. This represents a major shift in mental health science, traditionally focused on psychological and neuronal mechanisms of depression, psychosis and dementia. This book provides the first comprehensive overview of recent, inter-disciplinary research linking disordered function of the immune system to the brain and mental illness. It offers a broad and deep perspective on the implications of immune system involvement in psychiatric disorders, including a balanced focus on basic science and clinical applications. Chapters cover the scientific evidence linking immune processes to major mental illnesses such as schizophrenia, depression, anxiety and dementia. An invaluable guide for graduate students, doctors in training, scientific researchers and others interested in the link between the immune system and mental health.

This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the challenges ahead of incorporating this knowledge into clinical practice.

An essential book summarizing cutting-edge evidence on the role of the immune system and immunotherapies in psychiatric disorders.

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge professor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.

Many people consider stopping their psychiatric medications, but prescribers may not know how to do this in a collaborative, systematic way. This book describes the ins and outs of how clinicians can work closely with their patients to consider whether or not to try decreasing medications. It outlines the how and when, and gives recommendations on what the prescriber and patient may encounter along the way.

From renowned integrative physician Kenneth Bock, M.D., comes a groundbreaking approach to understanding adolescent and teen mental health disorders. Over the past decade, the number of 12- to 17-year-olds suffering from mental health disorders has more than doubled. While adolescents and teens are notorious for mood swings and rebellion, parents today are navigating new terrain as their children are increasingly at risk of struggling with a mental health issue. But the question remains: What is causing this epidemic of illness? In Brain Inflamed, acclaimed integrative doctor Dr. Kenneth Bock shares a revolutionary new view of adolescent and teen mental health—one that suggests many of the mental disorders most common among this population (including depression, anxiety, and OCD) may share the same underlying mechanism: systemic inflammation. In this groundbreaking work, Dr. Bock explains the essential role of the immune system and the microbiome in mental health, detailing the ways in which imbalances in these systems—such as autoimmune conditions, thyroid disorders, or leaky gut syndrome—can generate neurological inflammation. While most conventional doctors assume that teens’ psychological struggles can be resolved only with therapy and psychotropic drugs, Dr. Bock’s approach considers the whole-body health of his patients. In his integrative evaluations, he often uncovers triggers such as gluten sensitivity, adrenal dysfunction, Lyme disease, and post-strep infections—all of which create imbalances in the body that can generate psychological symptoms. Filled with incredible stories from Dr. Bock’s more than thirty years as a practicing physician, Brain Inflamed explains the biological underpinnings of many common mental health issues, and empowers the parents and family members of struggling teens with practical advice—and perhaps most importantly, hope for a brighter future.