Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS
Title | Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS PDF eBook |
Author | Swapan Chowdhury |
Publisher | Elsevier |
Pages | 355 |
Release | 2005-11-04 |
Genre | Science |
ISBN | 0080456065 |
As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners.* Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies·* Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them* Highlights problems associated with drug quantification and offers practical solutions
Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
Title | Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters PDF eBook |
Author | Shuguang Ma |
Publisher | Elsevier |
Pages | 710 |
Release | 2020-07-09 |
Genre | Science |
ISBN | 0128200197 |
Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. - Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues - Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included - Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics - All chapters are written by experts with a wide range of practical experience from the industry and academia
Mass Spectrometry in Drug Metabolism and Disposition
Title | Mass Spectrometry in Drug Metabolism and Disposition PDF eBook |
Author | Mike S. Lee |
Publisher | John Wiley & Sons |
Pages | 648 |
Release | 2011-03-16 |
Genre | Science |
ISBN | 0470934697 |
This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
Using Mass Spectrometry for Drug Metabolism Studies
Title | Using Mass Spectrometry for Drug Metabolism Studies PDF eBook |
Author | Walter A. Korfmacher |
Publisher | CRC Press |
Pages | 442 |
Release | 2009-11-03 |
Genre | Medical |
ISBN | 1420092219 |
The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the fiel
Drug Metabolism, Pharmacokinetics and Bioanalysis
Title | Drug Metabolism, Pharmacokinetics and Bioanalysis PDF eBook |
Author | Hye Suk Lee |
Publisher | MDPI |
Pages | 230 |
Release | 2019-06-12 |
Genre | Medical |
ISBN | 3038979163 |
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
Drug Transporters
Title | Drug Transporters PDF eBook |
Author | Martin F. Fromm |
Publisher | Springer Science & Business Media |
Pages | 457 |
Release | 2010-11-19 |
Genre | Medical |
ISBN | 3642145418 |
It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
Drug Metabolism
Title | Drug Metabolism PDF eBook |
Author | Katherine Dunnington |
Publisher | BoD – Books on Demand |
Pages | 110 |
Release | 2021-12-22 |
Genre | Medical |
ISBN | 1839688793 |
Drug metabolism comprises the identification, characterization, and quantification of the chemicals or compounds produced in an animal or human upon administration of a drug. Research practices not only require the chemical structure but also aim to determine the pharmacological activities and/or toxicity of these compounds. This is first performed in animals, as studies attempt to identify and quantify metabolites, and later in humans, with care to further characterize metabolites that are either unique to or produced disproportionately in humans compared to animals. Characterization includes the determination of enzyme systems or other biological mechanisms that produce each identified metabolite; this information is used to predict potential drug-drug interactions with other compounds that increase or decrease metabolite formation and sources of biological variability in response or toxicity with varying patient genetics, which affect CYP isoform expression. This book’s purpose is to provide some understanding of the biology and current technology applied in the field of drug metabolism.