William Byrd II (1674-1744) was an important figure in the history of colonial Virginia: a founder of Richmond, an active participant in Virginia politics, and the proprietor of one of the colony's greatest plantations. But Byrd is best known today for his diaries. Considered essential documents of private life in colonial America, they offer readers an unparalleled glimpse into the world of a Virginia gentleman. This book joins Byrd's Diary, Secret Diary, and other writings in securing his reputation as one of the most interesting men in colonial America. Edited and presented here for the first time, Byrd's commonplace book is a collection of moral wit and wisdom gleaned from reading and conversation. The nearly six hundred entries range in tone from hope to despair, trust to dissimulation, and reflect on issues as varied as science, religion, women, Alexander the Great, and the perils of love. A ten-part introduction presents an overview of Byrd's life and addresses such topics as his education and habits of reading and his endeavors to understand himself sexually, temperamentally, and religiously, as well as the history and cultural function of commonplacing. Extensive annotations discuss the sources, background, and significance of the entries.

Considers the theatrical fortunes of Richard II from its politically controversial beginnings on the Elizabethan and Restoration stage, to its various later interpretations responding to 19th- and 20th-century tastes and attitudes. A wide range of performances is documented and discussed. These illustrate the ways in which different theatres and companies have staged the play by cutting, restructuring or adding to Shakepeare's script to highlight spectacle, the personality of the King, the nature of authority and the place of Richard in the overall sweep of English history.

In The Problem of the Idea of Culture in John Paul II: Exposing the Disruptive Agency of the Philosophy of Karol Wojtyła, John Corrigan provides a new lens with which to view and understand the philosophy of Karol Wojtyła/John Paul II. He exposes Wojtyła as a major player in contemporary philosophical debates. The work reformulates the “problem of experience” in light of the questions surrounding our idea of culture. Corrigan argues that for Wojtyła the drama of the “problem of experience” manifests in the apparently divergent accounts of the meaning of human experience as presented by the philosophies of being and of consciousness. Solving this conundrum results in an idea of the person capable of explaining human experience in relation to human culture,unfolding the experiences of self-knowledge, conscience, and the ontic-causal relationship of the person to human culture. The first part of the book concerns formal considerations regarding the constitutive aspects of Wojtyła’s approach, while the second part deals with pragmatic considerations drawn from his comments on culture.

The collection of thirteen codices found in upper Egypt near Nag Hammadi in 1946 is one of the major archaeological discoveries of our time. Apparently the library of a Gnostic community in late antiquity, the codices are a repository of important spiritual materials from throughout the ancient world. Hence a thorough analysis of this new material is indispensable for any proper understanding of the history of religions in this period. The rich documentation which the codices add to early Coptic text material promises to raise to a new precision the historical analysis of that language.|This edition presents collotype reproductions in natural size of all folios of the thirteen codices as well as reproductions of the covers and photographs previously taken of fragments that are now lost.

Presents a biography of Karol Wojtyla, including his boyhood in Poland, his steps to the papacy, and his twenty-five years as Pope John Paul II.

A reliable, even-handed introduction to the to the Vatican Council II, "What Happened at Vatican II" is the first of its kind and a critical resource for understanding the Catholic church today, including the pontificate of Benedict XVI.

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.