Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.

From pre-historic grooming rituals to New Age medicine, from ascetics to cosmetics, Clean looks at how different cultures have interpreted and striven for personal cleanliness and shows how, throughout history, this striving for purity has brought immense social benefits as well as great tragedies. Looking at human history through the lens of public baths, lavatories, laundry, teeth cleaning, cosmetics, food storage and panty liners, Virginia Smith here combines archeology, psychology, biology, and other fields to illuminate our modern obsession cleanliness. She peppers her entertaining account with engaging and often surprising details. The book reveals, for instance, that even at the earliest stages of human development, our bodies produced pleasure-giving chemical opiates when things smelled or felt clean, inducing us to bathe or at least remove dirty clothes. She describes how, during the Bronze Age, an emerging hierarchy of wealthy elites turned their love of grooming into an explosion of the cosmetic and luxury goods industry, greatly affecting the culture and economy of Eurasia and leading to advances in chemistry and medicine. Likewise, in Greece and Rome, citizens focused much of their leisure time on perfecting, bathing, or just writing about the model athletic body. Even today, our enlightened medical knowledge could not stop an onslaught of health remedies, treatments, spas, and New Age nature cures--all in the pursuit of purity. This engrossing and highly original work will introduce you to the customs and ideas of a myriad of cultures across centuries of human history, providing a marvelous new perspective on the importance of cleanliness to human civilization.