HSPs - Ambiguous Mediators of Immunity
Title | HSPs - Ambiguous Mediators of Immunity PDF eBook |
Author | Stuart Keith Calderwood |
Publisher | Frontiers Media SA |
Pages | 94 |
Release | 2017-05-11 |
Genre | |
ISBN | 2889451526 |
Heat shock proteins (HSPs) were discovered as polypeptides induced by stress that can be found in all kingdoms of cellular organisms. Their functions were, a first enigmatic and these proteins were thus classified by molecular weight, as in—Hsp27, Hsp70, Hsp90, Hsp110. More recently, each of these size-classified molecules has attributed a role in protein folding, and they thus came to be known, as a class, as molecular chaperones. However, the they possess properties beyond chaperoning. Indeed, their discovery in the extracellular spaces suggested roles in regulation of the immune responses.
Toll-Like Receptors (TLRs) and Innate Immunity
Title | Toll-Like Receptors (TLRs) and Innate Immunity PDF eBook |
Author | Stefan Bauer |
Publisher | Springer Science & Business Media |
Pages | 243 |
Release | 2007-12-11 |
Genre | Medical |
ISBN | 3540721673 |
Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Heat Shock Proteins: Potent Mediators of Inflammation and Immunity
Title | Heat Shock Proteins: Potent Mediators of Inflammation and Immunity PDF eBook |
Author | Alexzander A.A. Asea |
Publisher | Springer Science & Business Media |
Pages | 356 |
Release | 2007-09-05 |
Genre | Medical |
ISBN | 1402055854 |
This book provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts’ immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step-wise fashion take the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provide answers as to its biological significance to the host.
Measles Virus Nucleoprotein
Title | Measles Virus Nucleoprotein PDF eBook |
Author | Sonia Longhi |
Publisher | Nova Publishers |
Pages | 180 |
Release | 2007 |
Genre | Medical |
ISBN | 9781600216299 |
Measles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNA-dependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. Indeed, beyond the phosphoprotein, NTAIL also interacts with cellular partners, including the major heat shock protein, hsp72, the interferon regulator factor 3, IRF3, and a yet unidentified cellular receptor referred to as NR. This book consists of two chapters devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties, and of three chapters focused on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners.
Cellular Stress and Inflammation: How the Immune System Drives Tissue Homeostasis
Title | Cellular Stress and Inflammation: How the Immune System Drives Tissue Homeostasis PDF eBook |
Author | Fabrizio Antonangeli |
Publisher | Frontiers Media SA |
Pages | 126 |
Release | 2021-05-10 |
Genre | Medical |
ISBN | 2889667537 |
Antiviral Substances (including Interferon).
Title | Antiviral Substances (including Interferon). PDF eBook |
Author | |
Publisher | |
Pages | 8 |
Release | 1977 |
Genre | Interferon |
ISBN |
Type 2 Immunity
Title | Type 2 Immunity PDF eBook |
Author | R. Lee Reinhardt |
Publisher | Humana |
Pages | 0 |
Release | 2018-06-29 |
Genre | Medical |
ISBN | 9781493978953 |
This book provides researchers the opportunity to investigate type-2-associated diseases in their laboratories. Beginning with chapters describing various models of type-2 immunity, the volume then continues by detailing cellular protocols designed to identify, characterize, and assess the function of key adaptive and innate immune cells involved in type-2 inflammation; approaches to isolate and evaluate specific cellular subsets at the genetic, epigenetic, and molecular level; protocols to assess type-2 immunity and its relationship to organismal and metabolic systems (ex. Microbiome). This book concludes with a section that explores the use of primary human cells in evaluating relevance to the clinic. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Vital and authoritative, Type 2 Immunity: Methods and Protocols aims to provide a broad network of methods that can be used to develop a hypothesis and investigate its potential from bench to beside.