During the past two decades, the world scientific community has witnessed major achievements in our understanding of the pathogenesis of HIV infection of the nervous system and HIV-Associated Dementia (HAD). Despite these giant gains, nervous system involvement during AIDS remains a relentlessly progressive disease with a deadly fate in many cases. This book on NeuroAIDS provides a unique resource for both general neurologists as well as basic neuroscientists with profound interests for research on NeuroAIDS. This book has special emphasis on the mechanisms of disease development and progression of HIV-infected patients with NeuroAIDS. The contributors have provided the readers with comprehensive reviews on clinical manifestations of HAD, mechanisms of HIV entry into the central nervous system, the role of cytokines and chemokines in pathogenesis of NeuroAIDS, drug abuse and NeuroAIDS, virus load in HAD, allostasis in HIV and AIDS, stroke in AIDS patients, and neuroimaging of HIV infection of the central nervous system. In addition, there are chapters on Varicella Zoster virus infection of HIV-seropositive and AIDS patients, as well as the molecular basis for opioids and AIDS virus interactions.

This book on NeuroAIDS, a collection of chapters written by experts and specialists from around the world, provides a global perspective on HIV and NeuroAIDS in the field, clinic, and laboratory. The chapters address the comorbidity of HIV and other infectious agents, including Zika virus, Ebola, Chagas disease, TB and HCV. Also discussed are key topics, such as: · Molecular socioepidemiology · Global HIV and NeuroAIDS · Neuropathology · cART and blood-brain barrier penetration · HIV replicative oscillations · HIV and SIV evolution · Psychiatric comorbidities · Neurosyphilis · The examination of current and innovative models of translational research to translational effectiveness

The Neurology of HIV Infection covers all aspects of nervous system involvement and pathology in HIV-infected individuals. Specialists in this field cover epidemiology, global aspects, pathology and pathogenesis of nervous system disease in HIV-infection. All complications, including the pathology caused by HIV itself and all opportunistic infections of the nervous system are reviewed in detail. Both central nervous and peripheral nervous system complications, including neuropathies and myopathies, are discussed. Key chapters on global developments, HIV-associated neurocognitive disorders, IRIS, stroke and neuro-aids in children complete this volume. - Covers all aspects of nervous system involvement and pathology in HIV-infected individuals - Includes the pathology caused by HIV and all opportunistic infections of the nervous system - Presents key chapters that focus on global developments, HIV-associated neurocognitive disorders, IRIS, stroke and neuro-aids in children

This text provides a clinical framework for the diagnosis and management of more than seventy potential neurological complications that may occur in the HIV infected patient. The clinical framework is designed to be "user friendly" so that even the most inexperienced clinician should be able to arrive at the correct diagnosis. The neurological complications of HIV disease have considerably changed in the last decade. Not only have more opportunistic conditions been described but other complications arising from antiretroviral drugs such as lipodystrophy and accelerated atherosclerosis have become problematic. Moreover, the pattern of complications has altered. Diseases such as cerebral toxoplasmosis, AIDS dementia complex and primary central nervous system lymphoma are now becoming uncommon to rare while peripheral neuropathy is becoming increasingly common. In line with these changes, there have been very significant advances in the therapy of HIV disease in general and in neurological complications in particular. Patients with AIDS dementia complex now have a variety of antiretroviral and adjuvant drugs available to them in contrast to the situation only five years ago where therapy was confined to two antiretroviral drugs at best.

The human immunodeficiency virus (HIV) commonly enters the central nervous system, disturbs brain function, and ultimately results in serious brain damage. The most serious manifestation of this infection of the brain is HIV-associated dementia, which includes severe memory loss, slowness in thinking, disorientation, and social incapacity. Most persons who are HIV infected do not develop severe dementia; however, perhaps 50% of those with AIDS and a smaller proportion of HIV-infected carriers suffer from more subtle brain disorders that can be revealed by proper neuropsychological testing. This book summarizes the current state of our knowledge about the neurocognitive disorders associated with HIV-1 infection. The book brings together contributions from leading authorities on the prevalence, qualitative features, natural course, and effects of neuropsychological impairments in persons with HIV infection. Neuropsychological data are related to findings from studies of brain imaging, neuropathology, and the effects of antiretroviral treatments.

Written and edited by leading international authorities in the field, this book provides an in-depth review of knowledge of tuberculosis of the central nervous system, with emphasis on clinical, diagnostics, and therapeutic features. Tuberculosis, one of the most lethal diseases in human history, still poses a serious threat in the world together with economic and social problems, although a great progress in the fight against this infectious disease in the last century. It covers the full range of tuberculosis of central nervous system and the chapters are organized into six sections: (1) the cranial; (2) the spinal; and (3) the peripheral portions of the nervous system; followed by (4) a section on the laboratory studies in tuberculosis; (5) a section on medical and surgical therapy; and (6) further insights into tuberculosis. This comprehensive reference book will be an ideal source for neurosurgeons, neurologists and specialists upon infectious diseases seeking both basic and more sophisticated information and surgical procedures relating to the complications associated with tuberculosis involving the spine, brain and peripheral nerves.