The most comprehensive state project of its kind, the Dictionary provides information on some 4,000 notable North Carolinians whose accomplishments and occasional misdeeds span four centuries. Much of the bibliographic information found in the six volumes has been compiled for the first time. All of the persons included are deceased. They are native North Carolinians, no matter where they made the contributions for which they are noted, or non-natives whose contributions were made in North Carolina.

Inventories were received from archives of the governing bodies of the various Protestant churches and of their missionary societies and from the libraries of their theological seminaries, colleges, and historical societies.