The South Carolina 2nd Regiment Rifles was organized during the spring of 1862 using the 5th South Carolina Battalion Rifles as its nucleus. It was organized from extra companies initially intended for Orr's Rifles. These companies were organized into a battalion that was officially designated the Fifth South Carolina Infantry Battalion. The unit served in South Carolina, then was ordered to Virginia and assigned to General Jenkins' and Bratton's Brigade. It participated in the Seven Days' Battles and the conflicts at Second Manassas, Sharpsburg, and Fredericksburg. Later the regiment was with Longstreet at Suffolk and D.H. Hill in North Carolina. It moved again with Longstreet but did not take part in the Battle of Chickamauga. The unit was involved in the Knoxville operations, returned to Virginia, and saw action at The Wilderness, Spotsylvania, and Cold Harbor. After enduring the hardships of the Petersburg siege south and north of the James River, it ended the war at Appomattox.

The South Carolina 2nd Infantry Regiment Rifles was organized during the spring of 1862 using the 5th South Carolina Battalion Rifles as its nucleus. The Second South Carolina Rifles was organized from extra companies initially intended for Orr's Rifles. These companies were organized into a battalion that was officially designated the Fifth South Carolina Infantry Battalion. The unit was known more popularly as the First South Carolina Rifle Battalion. The regiment fought for most of the war in Virginia. They went with Longstreet to Georgia, but did not participate in the Battle of Chickamauga. They were engaged at Knoxville however, before returning to Virginia. The remnants of the regiment surrendered at Appomattox. Company A - Abbeville District (County), a few from Laurens District (County) and Newberry District (County) Company B - Pickens District (County) now Oconee County Company C - Pickens District (County), now inOconee County Company D - Anderson District (County) and Pickens District (County) Company E - Pickens District (County), Anderson District District (County), and Greenville District (County) Company F - Pickens District (County), Anderson District (County), Abbeville District (County) Company G - Anderson District (County), Greenville District (County), and a few from Georgia Company H - Pickens District (County) Company I - Pickens District (Seigler says there was no Company I) Company K - Abbeville District (County), Anderson District (County) and Pickens District (County) Company L (possibly also known as the Butler Guards) - Anderson District (County), a few from Greenville District (County) and Spartanburg District (County)

The South Carolina 10th Infantry Regiment was organized at Camp Marion, near Georgetown, South Carolina, in July, 1861. Its members were raised in the counties of Georgetown, Horry, Williamsburg, Marion, and Charleston. The regiment moved to Cat Island where many of the men suffered from typhoid fever, measles, and mumps. In March, 1862, it was sent to Mississippi, then in the Kentucky Campaign it was involved in the capture of Munfordsville. During the war it was assigned to General Manigault's and Sharp's Brigade and from September, 1863 to April, 1864, was consolidated with the 19th Regiment. The unit served with the Army of Tennessee from Murfreesboro to Atlanta, endured Hood's winter campaign in Tennessee, and saw action in North Carolina. It lost 16 killed, 91 wounded, and 2 missing at Murfreesboro, and the 10th/19th had 236 killed or wounded at Chickamauga and totaled 436 men and 293 arms in December, 1863. During the Atlanta Campaign, July 20-28, the 10th Regiment lost 19 of 24 officers engaged.

The South Carolina 2nd Heavy Artillery Regiment also known as the 1st Artillery Regiment, was organized at Charleston, South Carolina, during the spring of 1862 using the 2nd South Carolina Artillery Battalion as its nucleus. This unit had enlisted in August, 1861, and went into service at Camp Butler, near Aiken. The 2nd Artillery spent the entire war in and around Charleston and completed their service fighting against Sherman in the Carolinas Campaign. Companies of the SC 2nd Artillery Regiment Company A - Barnwell District Company B - Barnwell and surrounding Districts Company C - Orangeburg District Company D - Darlington District and surrounding counties. Company E - Barnwell District, Aiken area. A few men from Lexington District and Edgefield District Company F - Orangeburg District (Branchville area) Company G - Barnwell District Company H - Barnwell District Company I - - Orangeburg District Company K - Edgefield District

The South Carolina 23rd Infantry Regiment [also called Coast Rangers] was assembled at Charleston, South Carolina, in November, 1861. Most of the men were from Horry, Georgetown, Charleston, and Colleton counties. After being stationed in South Carolina, the regiment moved to Virginia and during the war served in General Evans', Elliot's, and Wallace's Brigade.