The Louisiana 1st Volunteers Infantry Regiment completed its organization in April, 1861, at New Orleans, Louisiana. Ordered to Virginia, the unit served in the Department of Norfolk, then was assigned to A.R. Wright's, Starke's, Nicholl's, Iverson's, Stafford's, and York's Brigade, Army of Northern Virginia. It participated in the many difficult campaigns of the army from the Seven Days' Battles to Cold Harbor, marched with Early to the Shenandoah Valley, and ended the war at Appomattox. Companies Of The Louisiana 1st Infantry Regiment The companies of the 1st Louisiana were from Alexandria, New Orleans, and Shreveport. Company B became the Louisiana Guard Artillery Battery on July 21, 1861.

The 1st Regular Infantry Regiment, formerly the 1st Louisiana Militia Infantry, entered Confederate service in February, 1861. Most of the officers and men were from New Orleans and the immediate area. It served at Pensacola, then moved to Tennessee and took an active part in the Battle of Shiloh. After being on duty in Mississippi, the unit was assigned to Deas', Liddell's, and Gibson's Brigade. It participated in many conflicts from Murfreesboro to Nashville then served at Mobile. This regiment lost 8 killed, 71 wounded, and 23 missing at Murfreesboro, had 4 officers and 64 men in December, 1863, and during the Atlanta Campaign, May 9-27, reported 13 casualties. Only 39 men were present in November, 1864, and half that number were included in the surrender of the Department of Alabama, Mississippi, and East Louisiana. Companies of the Louisiana 1st Infantry Regiment - Strawbridge's Most of the men of this regiment were from New Orleans and the surrounding area.

The Louisiana 21st Infantry Regiment was formed in January, 1862, and mustered into Confederate service in February. Some of the men were recruited in Assumption and St. Helena parishes. The unit was stationed at New Orleans and captured when that city fell in April. After being exchanged, it served in L. Hebert's Brigade, Department of Mississippi and East Louisiana, and was captured again at Vicksburg. During the Vicksburg siege, the regiment lost 16 killed, 50 wounded, and 1 missing, and after the exchange in December, 1863, only 69 men were present. It was not reorganized. Some of the men served later in the Lousiana 22nd Infantry Regiment Consolidated.

The Louisiana 12th Infantry Regiment completed its organization at Camp Moore, Louisiana, in August, 1861. Its companies were from the parishes of Caldwell, Claiborne, Vermilion, Cameron, Calcasieu, Jackson, Ouachita, Bossier, and Iberia. Sent to Missouri, the unit was captured at Island No. 10 in April, 1862. After being exchanged, it was assigned to Rust's, Buford's, T.M. Scott's, and Lowry's Brigade. It fought at Champion's Hill and Jackson before participating in the campaigns of the Army of Tennessee from Resaca to Bentonville. In July, 1862, the unit contained 41 officers and 546 men, reported 11 killed, 57 wounded, and 5 missing out of the 318 engaged at Peach Tree Creek, lost many during Hood's Tennessee Campaign, and surrendered with only a remnant on April 26, 1865. Its commanders were Colonel Thomas M. Scott; Lieutenant Colonels James A. Boyd, Wade H. Hough, Noel L. Nelson, and Thomas C. Standifer; and Majors John C. Knott and Henry V. McCain.