This book describes the current status of the very rapidly developing field of high-field MR and examines the possibilities, challenges, and limitations of this fascinating technology. In the initial chapters, the basic technological background is explained in a non-technical way so as to promote understanding of the issues and concepts and avoid overwhelming the reader with excessive detail. Safety issues, methods, and contrast are then carefully considered. The final part of the book examines the diverse applications of high-field MR imaging in radiology, neuroscience, oncology, and other fields, with the aid of numerous high-quality illustrations. All chapters are written by leading experts who have taken great care to illustrate the potential and progress of the field in an informative and accessible manner. The book will appeal to all with a potential interest in the application of high-field MR imaging, including radiologists, neuroscientists, and oncologists.

Guide to Techniques in Mouse Development, Part A comprehensively covers new technologies and methodologies that have appeared for the study of mouse development. - Update of volume 225 of Methods in Enzymology, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993 - Covers new technologies and methodologies, including: - new techniques for the cryopreservation of gametes and embryos - production of transgenic and null (knockout) animals (use of ES cells) - generation of conditional/inducible mutant animals - use of gene-trap mutagenesis - analysis of allele-specific expresion - use of new reporter constructs - humanizing of transgenic animals - transcript profiling of mouse development - imaging of mouse development - rederivation of animals and use of mouse genomics

The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.

Genome science or genomics is essential to advancing knowledge in the fields of biology and medicine. Specifically, researchers learn about the molecular biology behind genetic expression in living organisms and related methods of treating human genetic diseases (including gene therapy). Advances in Genome Science is an e-book series which provides a multi-disciplinary view of some of the latest developments in genome research, allowing readers to capture the essentiality and diversity of genomics in contemporary science.

Magnetic Resonance Microscopy Explore the interdisciplinary applications of magnetic resonance microscopy in this one-of-a-kind resource In Magnetic Resonance Microscopy: Instrumentation and Applications in Engineering, Life Science and Energy Research, a team of distinguished researchers delivers a comprehensive exploration of the use of magnetic resonance microscopy (MRM) and similar techniques in an interdisciplinary milieux. Opening with a section on hardware and methodology, the book moves on to consider developments in the field of mobile nuclear magnetic resonance. Essential processes, including filtration, multi-phase flow and transport, and a wide range of systems – from biomarkers via single cells to plants and biofilms – are discussed next. After a fulsome treatment of MRM in the field of energy research, the editors conclude the book with a chapter extoling the virtues of a holistic treatment of theory and application in MRM. Magnetic Resonance Microscopy: Instrumentation and Applications in Engineering, Life Science and Energy Research also includes: A thorough introduction to recent developments in magnetic resonance microscopy hardware and methods, including ceramic coils for MR microscopy Comprehensive explorations of applications in chemical engineering, including ultra-fast MR techniques to image multi-phase flow in pipes and reactors Practical discussions of applications in the life sciences, including MRI of single cells labelled with super paramagnetic iron oxide nanoparticles In-depth examinations of new applications in energy research, including spectroscopic imaging of devices for electrochemical storage Perfect for practicing scientists from all fields, Magnetic Resonance Microscopy: Instrumentation and Applications in Engineering, Life Science and Energy Research is an ideal resource for anyone seeking a one-stop guide to magnetic resonance microscopy for engineers, life scientists, and energy researchers.

The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

Although nuclear magnetic resonance is perhaps best known for its spectacular utility in medical tomography, its potential applicability to fields such as biology, materials science, and chemical physics is being increasingly recognized as laboratory NMR spectrometers are adapted to enable small scale imaging. This excellent introduction to the subject explores principles and common themes underlying two key variants of NMR microscopy, and provides many examples of their use. Methods discussed are not only important to fundamental biological and physical research, but have applications to a wide variety of industries, including those concerned with petrochemicals, polymers, biotechnology, food processing, and natural product processing. The wide range of scientists interested in NMR microscopy will want to own a copy of this book.