Discusses his health and family matters. Talks about gaining weight, stating I have increased since your departure, owing perhaps to two causes ... more food and less exercise. Mentions that the President (George Washington) has invited him to Mount Vernon. Discusses financial matters and worries about his wife's health.

Expresses his happiness on hearing that his wife is doing well and writes that I shall give you all possible proofs of my affection. Makes plans to see her soon and sends her his brother's love.

Declares that he is anxious about Lucy's health, and is checking every post ... more and more so until I shall informed of your having been safely delivered. Provides news on acquaintances, and mentions that he has yet to receive confirmation that [William] Duer will agree to sell. This is unfortunate as it will require him to make another trip to New York. Also discusses the weather, and sends his love to the family.

Discusses plans for his son's education and is happy to hear that his brother William is back from Dublin, Ireland. Writes to Lucy about mutual acquaintances, mentioning that one family just had a baby girl.

Mentions being attacked with the cursed fever last week, but is now better. Wishes he could be with her and the family. Informs that Mrs. Smith is doing better after being very ill with a disorder in her bowels. Writes that Our President [George Washington], Mrs. Washington and family departed yesterday... Writes of events in England and France exclaiming, What unpleasant work on the frontiers of France! - England will go into confusion - do you not think Tom Paine has excited great commotion in mens minds to be honored with a royal Proclamation against his writings.

Writes that he expects she will receive this letter when she arrives in Boston. Discusses her travels and visits with friends, as well as the weather. Remarks at length that he is concerned about the safety of her and the children en route to Boston, and wishes he could hear from her hourly. Declares if he could, he would protect her from every possible ill. Mentions that he is lonely in his house, and hopes Lucy will remember him tenderly. Sends his love to the children, his sister-in-law Mrs. [Sarah Lyons] Flucker and her children, as well as to his friend Harry [Henry Jackson].

Complains that though the post has arrived, he has not received any letters from his wife. Laments that he was not able to visit her. Mentions the Izard family arriving in a few days. Free frank stamped as Free and signed by Henry Knox.