Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive datab

Over the years, researchers have reported solubility data in the chemical, pharmaceutical, engineering, and environmental literature for several thousand organic compounds. Until the first publication of the Handbook of Aqueous Solubility Data, this information had been scattered throughout numerous sources. Now newly revised, the second edition of

Over the years researchers have reported solubility data in the chemical, pharmaceutical, engineering, and environmental literature for several thousand organic compounds. Until now, this information has been scattered throughout the literature. Containing over 16,000 solubility data points for more than 4,000 organic compounds, Handbook of Aqueous

Hansen solubility parameters (HSPs) are used to predict molecular affinities, solubility, and solubility-related phenomena. Revised and updated throughout, Hansen Solubility Parameters: A User's Handbook, Second Edition features the three Hansen solubility parameters for over 1200 chemicals and correlations for over 400 materials including p

As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have m

This 4th edition of Handbook of Solvents, Volume 2, contains the most comprehensive information ever published on solvents as well as an extensive analysis of the principles of solvent selection and use. The book begins with a discussion of solvents used in over 30 industries which are the main consumers of solvents. The analysis is conducted based on the available data and contains information on the types (and frequently amounts) of solvents used and potential problems and solutions. Picking up where Handbook of Solvents, Volume 1 leaves off, Handbook of Solvents Volume 2 provides information on the methods of analysis of solvents and materials containing solvents, with 2 sections containing standard and special methods of solvent analysis, followed by a discussion of residual solvents left in the final products. The environmental impact of solvents, such as their fate and movement in the water, soil, and air, fate-based management of solvent-containing wastes, and ecotoxicological effects are discussed as are solvents' impact on tropospheric air pollution. The next 2 chapters are devoted to the toxicology of solvents and regulations aiming to keep solvent toxicity under control. The analysis of the concentration of solvents in more than 15 industries, specific issues related to the paint industry, and characteristics of the environment in automotive collision repair shops are followed by a thorough discussion of regulations in the USA and Europe. Following chapters show examples of solvent substitution by safer materials, with an emphasis on supercritical solvents, ionic liquids, deep eutectic solvents, and agriculture-based products, such as ethyl lactate. Discussion of solvent recycling, removal, and degradation includes absorptive solvent recovery, comparison of results of recovery and incineration, and application of solar photocatalytic oxidation. The book concludes with an evaluation of methods of natural attenuation of various solvents in soils and modern methods of cleaning contaminated soils. - Assists in solvent selection by providing key information and insight on environmental and safety issues - Provides essential best practice guidance for human health consideration - Discusses the latest advances and trends in solvent technology, including modern methods of cleaning contaminated soils, selection of gloves, suits, and respirators

Crystallization is an important separation and purification process used in industries ranging from bulk commodity chemicals to specialty chemicals and pharmaceuticals. In recent years, a number of environmental applications have also come to rely on crystallization in waste treatment and recycling processes.The authors provide an introduction to the field of newcomers and a reference to those involved in the various aspects of industrial crystallization. It is a complete volume covering all aspects of industrial crystallization, including material related to both fundamentals and applications. This new edition presents detailed material on crystallization of biomolecules, precipitation, impurity-crystal interactions, solubility, and design.Provides an ideal introduction for industrial crystallization newcomers Serves as a worthwhile reference to anyone involved in the fieldCovers all aspects of industrial crystallization in a single, complete volume