The book includes six chapters that cover Virginia history from initial settlement through the 20th century plus one that deals with the important role of underwater archaeology. Written by prominent archaeologists with research experience in their respective topic areas, the chapters consider important issues of Virginia history and consider how the discipline of historic archaeology has addressed them and needs to address them . Changes in research strategy over time are discussed , and recommendations are made concerning the need to recognize the diverse and often differing roles and impacts that characterized the different regions of Virginia over the course of its historic past. Significant issues in Virginia history needing greater study are identified.

Grayson County is famous in southwestern Virginia as the cradle of the New River settlements--perhaps the first settlements beyond the Alleghanies. The Nuckolls book is equally famous for its genealogies of the pioneer settlers of the county, which, typically, provide the names of the progenitors of the Grayson County line and their dates and places of migration and settlement, and then, in fluid progression, the names of all offspring in the direct and sometimes collateral lines of descent. Altogether somewhere in the neighborhood of 4,000 persons are named in the genealogies and indexed for ready reference.

This guide explores Virginia and its history on U.S. Highways 11, 15, 17, 50, and 60, as well as the Blue Ridge Parkway and Skyline Drive. Historical text for each site and landmark along the highways are derived from the American Guides of the 1930's and 40's. Reference maps and GPS Coordinates for all listed sites are included.