The debate on whether to privilege economic growth over ecological security is passé. Environmental considerations must be at the heart of economic growth, especially for a country of 1.25 billion people destined to add another 400 million by the middle of the century. Green Signals chronicles the '1991 moment' in India's environmental decision-making, telling the story of how, for the first time, the doors of the environment ministry were opened to voices, hitherto unheard, into the policy-making process. It details efforts to change the way environment is viewed both by proponents of environmental security and those who prize economic growth at all costs. Told from the perspective of a pivotal decision maker, the book addresses the challenges involved in trying to ensure economic growth with ecological security. It takes us through India's coming of age in the global environmental and climate change community to take on a leadership role that is progressive, proactive, and steeped in national interest. Using speaking orders on high-profile projects, notes and letters to the Prime Minister, ministerial colleagues, chief ministers and others, Jairam Ramesh gives an insight into the debates, struggles, challenges, and obstacles to bringing environmental considerations into the mainstream of political and economic decision-making. This collection reveals the story of the author's attempt at the highest levels of governance to introduce effective decision-making, a transparent and accountable administration, and to make environmental concerns an essential component of a nation's quest to accelerate economic growth and end the scourge of poverty and deprivation.

The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.

Cytogenetic Laboratory Management Cytogenetic Laboratory Management Chromosomal, FISH and Microarray-Based Best Practices and Procedures Cytogenetic Laboratory Management: Chromosomal, FISH and Microarray-Based Best Practices and Procedures is a practical guide that describes how to develop and implement best practice processes and procedures in the genetic laboratory setting. The text first describes good laboratory practices, including quality management, design control of tests, and FDA guidelines for laboratory-developed tests, and preclinical validation study designs. The second focus of the book is on best practices for staffing and training, including cost of testing, staffing requirements, process improvement using Six Sigma techniques, training and competency guidelines, and complete training programs for cytogenetic and molecular genetic technologists. The third part of the text provides stepwise standard operating procedures for chromosomal, FISH and microarray-based tests, including preanalytic, analytic, and postanalytic steps in testing, which are divided into categories by specimen type and test type. All three sections of the book include example worksheets, procedures, and other illustrative examples that can be downloaded from the Wiley website to be used directly without having to develop prototypes in your laboratory. Providing a wealth of information on both laboratory management and molecular and cytogenetic testing, Cytogenetic Laboratory Management will be an essential tool for laboratorians worldwide in the field of laboratory testing and genetic testing in particular. This book gives the essentials of: Developing and implementing good quality management programs in laboratories Understanding design control of tests and preclinical validation studies and reports FDA guidelines for laboratory-developed tests Use of reagents, instruments, and equipment Cost of testing assessment and process improvement using Six Sigma methodology Staffing training and competency objectives Complete training programs for molecular and cytogenetic technologists Standard operating procedures for all components of chromosomal analysis, FISH, and microarray testing of different specimen types This volume is a companion to Cytogenetic Abnormalities: Chromosomal, FISH and Microarray-Based Clinical Reporting. The combined volumes give an expansive approach to performing, reporting, and interpreting cytogenetic laboratory testing and the necessary management practices, staff and testing requirements.

This book includes a description of the activities of ECMT and information trends in transport in europe in 1988, along with texts of all resolutions and reports approved during that period.