The significant progress in the understanding of the pathogenesis and the treatment of Graves’ orbitopathy (GO) has warranted a second edition of this book within three years of the first. Now also fully incorporated is the EUGOGO consensus statement on management of GO, which since has been accepted worldwide as a useful guideline. Furthermore all chapters have been thoroughly updated. Subjects covered include the pathology of GO and the controversial views on its pathogenesis; assessment of changes using reliable measuring techniques; medical management of GO including established and alternative treatment options; technical explanations and illustrations of various surgical procedures and finally, the molecular, immunologic, and clinical aspects of this complex disorder. Two new chapters have been added: one describing the socioeconomic impact of the disease and the other outlining the Amsterdam Declaration on Graves’ Orbitopathy. The successful question-and-answer format facilitates its use as a reference guide for medical practitioners and surgeons working in the fields of ophthalmology, internal medicine, endocrinology, pediatrics, immunology, as well as otorhinolaryngology.

In recent years, close interdisciplinary cooperation of numerous international experts, both clinicians and basic scientists, within the European Group of Graves' orbitopathy (EUGOGO) has yielded much valuable progress and new information, which this publication brings together. Subjects covered include the pathology of Graves' orbitopathy (GO) and the controversial views on its pathogenesis; assessment of changes using reliable measuring techniques; medical management of GO including established and alternative treatment options; technical explanations and illustrations of various surgical procedures and finally, the molecular, immunologic, and clinical aspects of this complex disorder. Stressing the current management of thyroid eye disease, this book offers medical practitioners a thorough overview of associated changes in the eyes of patients with GO. Therefore, this publication is an essential resource for ophthalmologists, internists, endocrinologists, pediatricians, immunologists, specialists in nuclear medicine, neuroradiologists and radiotherapists, specialists in laboratory medicine and pathology, otorhinolaryngologists, orbital and neurosurgeons as well as oral and maxillofacial surgeons.

In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.

This indispensable volume is designed to facilitate the best possible physician?patient discussion on Graves? disease by providing the most up-to-date evidence-based information in a clinically useful and patient-centric manner. Comprehensive and covering such topics as Professionalism and the Art of Patient-centric Thyroidology, the Immunopathogenesis of Graves? Disease, and the Diagnosis and Management of Thyroid Storm, the book addresses all the important refinements in the treatment of Graves? disease in recent years. These include new indications and contraindications for antithyroid drugs, improved approaches to radioactive iodine therapy, the development of novel surgical techniques, and a better understanding of the combined use of these modalities, among other developments. Also addressed are the advances in the treatment of GO, including the use of disease activity and severity assessments to inform management decisions and the completion of the first randomized controlled therapeutic trials. Developed by a renowned group of internationally respected authorities, Graves? Disease: A Comprehensive Guide for Clinicians is a significant new reference that will be of great interest to all clinicians who treat this debilitating condition.

Now in a revised and expanded third edition, this case-based guide emphasizes the latest investigative advances in both imaging and molecular diagnostics and new treatment approaches for a wide variety of common and complex endocrine conditions. Utilizing unique clinical case histories, each main endocrine condition and disorder is curated by a senior Section Editor with an introduction to his or her area covering both physiology and pathophysiology. This introductory chapter is followed by a number of case histories written by invited experts and designed to cover the important relevant pathophysiology, following a consistent chapter format for ease of use, including bulleted objectives, case presentations, review of the diagnosis, lessons learned, and 3-5 multiple-choice review questions. Section headings include the pituitary, thyroid (overactivity, underactivity and cancer) and parathyroid, adrenal disorders, metabolic bone disease, type 2 diabetes, lipid abnormalities, obesity, and pregnancy. Topics new to this edition include PCOS, transgender medicine and the endocrine effects of viral infections. With a focus on covering major parts of the APDEM curriculum, A Case-Based Guide to Clinical Endocrinology remains a tremendous resource for junior and veteran clinicians alike.

Now thoroughly revised, this Second Edition text focuses on a case-based learning approach that features decision-making information presented in algorithmic format. Sections covered are the anatomy of the orbit, pathophysiologic and anatomic principles in classifying, diagnosing and investigating orbital disease, diseases of the orbit, and the management of those diseases. New topics include orbital ultrasound, gamma scanning, magnetic resonance imaging, incidence of lesions by location, management of complex vascular lesions, granulomatous inflammations of the orbit, and orbital atrophy. A conceptual model is presented and a new classification scheme discussed. Several chapters have been updated and illustrations are plentiful.