Loomis's Essentials of Toxicology, Fifth Edition, provides the information on the harmful biologic effects associated with exposures to chemicals of all types. The scope of this book includes a discussion of the major types of chemicals involved, their general properties and detrimental biologic effects, the methods used to demonstrate these effects, the basis for clinical diagnosis, and therapy for the harmful effects of chemicals on humans. Individual examples are used to demonstrate the principle discussed. This reference volume will be an invaluable resource for both toxicologists and graduate and advanced undergraduate students in toxicology and public health. - Provides a revised and updated edition of one of the "gold" works in the field - Includes both principles and methods - Requires minimal background in chemistry and biology - Expanded Information Sources in Toxicology

Ecotoxicology Essentials: Environmental Contaminants and Their Biological Effects on Animals and Plants provides a fundamental understanding of this area for students and professionals in ecotoxicology, ecology, conservation, chemistry, public health, wildlife management, fisheries, and many other disciplines. Although new chemicals and potential problems are developed every year, a basic education is essential to address these new challenges, and this work gives such training. Written with the regulatory framework in mind, the material guides readers on modelling, how to conduct assessments, and human and wildlife risk, focusing on effects on animals rather than transport of chemicals. Simple discussions of chemistry are complemented by coverage on the behavior of the animal, dynamics of the ecosystem, real-life situations like drought, and predators in the system – i.e., the natural system versus the lab setting. The book's first section contains chapters on the principles of contaminant toxicology including a brief history of the science of ecotoxicology, basic principles of the science, testing methods, and ways of determining if animals have been exposed to either acute or chronic concentrations of contaminants. The second section deals with the primary classes of contaminants including their chemical characteristics, sources, uses, and effects on organisms. The third section focuses on more complex issues such as the regulation of pollution, population and community effects, risk assessment and modelling. - Uses examples from both aquatic and terrestrial environments and species - Includes a Terms to Know section and a list of study questions in each chapter, fostering a greater understanding of the issues - Focuses on the effects of contaminants on wildlife while providing enough chemistry to allow a detailed understanding of the various contaminant groups - Emphasizes natural examples and 'real' species, rather than laboratory studies on only a handful of organisms - Features case histories, detailing actual events that include aspects of how the contamination occurred and its effects on wildlife - Provides material from a wide variety of international sources

Concise and easy to follow, this book explains the implementation of Good Laboratory Practices (GLPs). The second edition of a standard reference, GLP Essentials identifies and describes the required elements of managing a scientific study including its planning, performance, reporting, and monitoring. The author includes a brief, informative discussion of the historical development of GLPs and the rationale for establishing these requirements in the rapidly expanding scientific research and regulatory environment. Written especially for readers involved in ensuring the integrity of their scientific documentation, this book is useful for individual and group training programs.

This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.

Essential Developmental Biology ist eine umfassende und reich illustrierte Einführung in sämtliche Aspekte der Entwicklungsbiologie. Die 3. Auflage dieses beliebten und zugänglichen Lehrbuchs wurde erweitert und aktualisiert. Die begleitende Website bietet darüber hinaus Lehr- und Lernmaterialien für Studenten und Dozenten, animierte Entwicklungsprozesse, eine Fotogalerie ausgewählter Modellorganismen und sämtliche Abbildungen usw. der Printversion zum Herunterladen. Dieses evidenzbasierte Lehrbuch liefert durchgängig Belege für zentrale Schlussfolgerungen und ist ein Muss sowohl für Einführungs- als auch Aufbaukurse der Entwicklungsbiologie.

The Essentials are an international, best-selling series of textbooks, all of which are designed to support lecture series or themes on core topics within the health sciences. See www.wiley.com for further details. Essential Endocrinology and Diabetes provides the accurate and up-to-date knowledge required for treating all areas of endocrinology and diabetes, covering the latest research, clinical guidelines, investigational methods, and therapies. This classic text explains the vital aspects of endocrine physiology in a succinct and easy-to-use format, with full-colour illustrations, clinical images, and case studies to assist readers in applying theory to practice. The text covers the principles of endocrinology, clinical endocrinology, and clinical diabetes and obesity, and has been revised throughout to present the most recent developments in the field. The seventh edition includes new and updated material on the latest molecular techniques, approaches to clinical investigation and diagnostics, next generation sequencing technology, and positron emission tomography (PET). The treatment of type 1 diabetes and type 2 diabetes has been updated with clinical algorithms and reflects significant advances such as incretin-based therapies, SGLT2 inhibitors, the development of better insulins, and technologies that support self-management. Provides students and practitioners with comprehensive and authoritative information on all major aspects of endocrine physiology Covers diagnosis, management, and complications of clinical disorders such as endocrine neoplasia, and type 1 diabetes and type 2 diabetes Explains the core principle of feedback regulation, which is vital for the correct interpretation of many clinical tests Features case histories, learning objectives, ‘recap’ links to chapter content, cross-referencing guides, key information boxes, and chapter summaries Essential Endocrinology and Diabetes, Seventh Edition is the ideal textbook for medical and biomedical students, junior doctors, and clinicians looking to refresh their knowledge of endocrine science. For more information on the complete range of Wiley medical student and junior doctor publishing, please visit: www.wiley.com To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email All content reviewed by students for students Wiley Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind. If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more. This title is also available as an e-book. For more details, please see www.wiley.com/buy/9781118763964

Essential Elements for a GMP Analytical Chemistry Department is a systematic approach to understanding the essential elements required for a successful GMP Analytical Department to function as an efficient and effective organization. It describes in detail a department structure which allows for the necessary processes to become available to all its personnel in a way where there is a free flow of information and interaction. The environment and culture created by this approach encourages and rewards the sharing of ideas, skills, and abilities among department personnel. The essential elements such as , SOP’s, regulatory guidance’s/guidelines, project teams, technical and department processes, personnel motivation, outsourcing, and hiring the best is among the many topics that are discussed in detail and how they can be implemented to build an efficient and effective Analytical Department. This book will serve as a valuable asset to the many companies required to perform GMP analytical method development, validation, analyses etc including start-up, virtual, and generic pharmaceutical companies. ​