Genotoxic and Carcinogenic Metals
Title | Genotoxic and Carcinogenic Metals PDF eBook |
Author | Lawrence Fishbein |
Publisher | |
Pages | 360 |
Release | 1987 |
Genre | Carcinogenesis |
ISBN |
The Carcinogenicity of Metals
Title | The Carcinogenicity of Metals PDF eBook |
Author | Alan B. G. Lansdown |
Publisher | Royal Society of Chemistry |
Pages | 449 |
Release | 2013-10-31 |
Genre | Science |
ISBN | 1849737193 |
This book re-evaluates epidemiological and occupational health studies, experimental studies in animals and in vitro experiments relating to the toxicity of 27 metal and metalloid elements for which evidence of carcinogenicity has been presented. Human carcinogenic risk is substantiated in relation to arsenic, beryllium, thorium, chromium, radioactive elements, probably lead, and some nickel and cobalt compounds, and respirable silica particles, but the carcinogenicity of iron, aluminium, titanium, tungsten, antimony, bismuth, mercury, precious metals, and certain related compounds in humans is unresolved. The toxicity and carcinogenicity of each element is specific but correlates poorly with its position in the Periodic Table. Carcinogenicity differs according to the valency of the ion and its ability to interact with and penetrate membranes in target cells and to bind, denature or induce mutations by genotoxic or epigenetic mechanisms. This important text comprehensively examines each of the elements providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. The book is an essential tool for toxicologists, medicinal and biochemists, and environmental scientists working in both industry and academia.
Mechanisms of Carcinogenesis
Title | Mechanisms of Carcinogenesis PDF eBook |
Author | Elizabeth K. Weisburger |
Publisher | Springer Science & Business Media |
Pages | 210 |
Release | 2012-12-06 |
Genre | Medical |
ISBN | 9400925263 |
but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.
Genotoxic and Carcinogenic Metals: Environmental and Occupational Occurrence and Exposure (Volume 11).
Title | Genotoxic and Carcinogenic Metals: Environmental and Occupational Occurrence and Exposure (Volume 11). PDF eBook |
Author | L Fishbein (Ed) |
Publisher | |
Pages | |
Release | 1987 |
Genre | |
ISBN |
Arsenic. Selenium. Beryllium, Chromium. Cadmium. Nickel. Mercury. Lead. Bioavailability and Interaction of Metals: General Considerations. Biological Monitoring of Metals: An Overview. Metal Interactions in Carcinogenesis. Toward Mechanisms of Metal Carcinogenesis.
Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment
Title | Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment PDF eBook |
Author | N. Hadjiliadis |
Publisher | Springer Science & Business Media |
Pages | 634 |
Release | 2012-12-06 |
Genre | Science |
ISBN | 9401157804 |
Environmental pollution is one of the main problems to confront humanity, with the heavy metals occupying a leading role among the most pernicious pollutants. The metals cause cancer and other sicknesses. Their cytotoxic, mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines. But the effects of heavy metals are not all negative: some, like cis-DDP, and some ruthenium and tin complexes, have antitumour activity. The idea underlying the present work is therefore to present a multidisciplinary perspective on heavy metals in the environment, affording a better understanding of their action on human organisms and health, aiming to make them less polluting and more environmentally friendly.
Cellular Effects of Heavy Metals
Title | Cellular Effects of Heavy Metals PDF eBook |
Author | Gaspar Banfalvi |
Publisher | Springer Science & Business Media |
Pages | 348 |
Release | 2011-03-02 |
Genre | Medical |
ISBN | 9400704283 |
The term “heavy metals” is used as a group name of toxic metals and metalloids (semimetals) causing contaminations and ecotoxicity. In strict chemical sense the density of heavy metals is higher than 5 g/cm3. From biological point of view as microelements they can be divided into two major groups. a. For their physiological function organisms and cells require essential microelements such as iron, chromium (III), cobalt, copper, manganese, molidenium, zinc. b. The other group of heavy metals is toxic to the health or environment. Of highest concern are the emissions of As, Cd, Co, Cu, Hg, Mn, Ni, Pb, Sn, Tl. The toxicity of heavy metals is well known at organizational level, while less attention has been paid to their cellular effects. This book describes the toxicity of heavy metals on microorganisms, yeast, plant and animal cells. Other chapters of the book deal with their genotoxic, mutagenic and carcinogenic effects. The toxicity of several metals touch upon the aspects of environmental hazard, ecosystems and human health. Among the cellular responses of heavy metals irregularities in cellular mechanisms such as gene expression, protein folding, stress signaling pathways are among the most important ones. The final chapters deal with biosensors and removal of heavy metals. As everybody is eating, drinking and exposed to heavy metals on a daily basis, the spirit of the book will attract a wide audience.
Genetic Response to Metals
Title | Genetic Response to Metals PDF eBook |
Author | Sarkar |
Publisher | CRC Press |
Pages | 514 |
Release | 1995-04-19 |
Genre | Science |
ISBN | 9780824796150 |
"Based on the First International Symposium on Metals and Genetics held recently at the Hospital for Sick Children in Toronto, Ontario, Canada. The only book of its kind to focus on the effects of metals on DNA. Provides up-to-date information on new developments in the field and their wide-ranging implications. Discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity."