Thoroughly revised for its Third Edition, this volume is the most comprehensive, multidisciplinary text on genitourinary cancers. This edition has two new editors—Frans M.J. Debruyne and W. Marston Linehan—and more than 50% new contributors. Seventeen new chapters cover familial prostate cancer, biology of bone metastases, molecular pathology and biologic determinants, PSA and related kallikreins, needle biopsy, laparoscopic surgical procedures, 3D conformal radiotherapy, hormones and radiotherapy, integration of chemotherapy and other modalities, quality of life after treatment of localized prostate cancer, management of rising PSA after local therapy, the role of surgery in advanced bladder cancer, post-chemotherapy node dissections and resection of metastatic disease, and stem cell transplantation.

Rare Genitourinary Tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. Each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. A valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular pathology and, where applicable, data from clinical trials. The practical treatment guidelines included for each tumor type are written by experts and fully referenced.

This book provides a quick reference guide for clinicians in radiation oncology. It is designed to be an intuitive and easily reviewed study guide for board or maintenance of certification examinations, as well as a quick reference for residents and established radiation oncologists who need a refresher. The text begins with a general pearls chapter that radiation oncologists should consider in all aspects of their practice, including cancer visibility, dosing, counseling recommendations, and toxicity management. The subsequent chapters then delve into different cancer disease sites, including pediatrics, central nervous system, head and neck, thoracic, breast, gastrointestinal, gynecologic, genitourinary, hematologic, soft tissue, palliative, and radiophysics/radiobiology. Within each chapter, each disease and its recommended approach is then summarized in only a few pages, allowing a focus on the most essential information. Bullet points, figures, tables, and images make for an intuitive reader experience. Recommendations are taken from the American Society for Radiation Oncology (ASTRO), the European Society for Radiation Oncology (ESTRO), and the National Comprehensive Cancer Network (NCCN). Planning guides for imaging, diagnosis, and staging offer readers a starting point in approaching each patient based on disease origin, and dosing guidelines then detail consideration for treatment methods. Each chapter additionally includes disease-specific pearls and key points to test the knowledge reviewed in the chapters. Experts in the disease sites from the United States serve as senior authors on each chapter. The authors include all diseases associated with radiation oncology training to ensure a comprehensive resource for exam studying and clinical care. Residents, trainees, and established radiation oncologists find this an ideal study resource for both board and certification exams, as well as an easily accessible aid during practice.

This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techniques for urologic cancers, the impacts of care coordination pathways and enhanced recovery after surgery protocols are reviewed. Readers will also find enlightening discussion of the decision algorithm for the treatment of early-stage, high-grade bladder cancer, taking into account evidence on the most advanced treatment options and the circumstances in which surgery may need to be expedited. The penultimate chapter discusses the Cancer Genome Atlas project for bladder cancer, and the book closes by considering contemporary medical and surgical management of testicular cancer.

Selected from the world’s leading comprehensive cancer textbook, this tightly focused resource provides you with the practical, cutting-edge information you need to provide the best cancer care to each patient. Prostate and Other Genitourinary Cancers: Cancer: Principles & Practice of Oncology, 10th Edition, offers a comprehensive and balanced view of this rapidly changing field, meeting the needs of oncology practitioners, fellows, and others who need an in-depth understanding of prostate and GU cancer. The print reference gives you the solid, dependable guidance you’ve come to expect from this outstanding title, and the Inkling version features new quarterly updates written by a team of experts selected by the authors.

Immunological Implications and Molecular Diagnostics of Genitourinary Cancer updates on recent accomplishments, unifying concepts, and future challenges in the study of tumor-associated immune cells, emphasizing genitourinary cancers. The presence of inflammatory immune cells in human tumors raise a fundamental question: How do cancer cells avoid destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells, however, as tumors develop from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms. This book covers research on the immunological implications of genitourinary cancer with a comprehensive view, especially surrounding diagnosis and cellular mechanisms. Discusses the impact of the immune system on the initiation, progression and treatment of cancer Provides insights on the important role of the suppressor genes and oncogenes in genitourinary cancers Shows the advantages of combining clinical issues of urologic cancers with immunological techniques, like immunohistochemistry and immunofluorescence Demonstrates the implications genitourinary cancer has on the human innate immune system

Malignant disease of the genitourinary tract continues to provide a major health hazard. The study of these disease processes has been hampered at the clinical level as there has been a serious lack of reasonably controlled treatment trials, and at the basic science level as many of the animal model systems do not compare favorably with the human tumor situation. This volume defines current cancer treatment and research and its appli cation to the control of human genitourinary malignancy. The authors have developed their chapters in such a way as to provide an up-to-date resource for the clinician who is involved in day-to-day patient care problems, for the clinician-investigator who is attempting to construct programs designed to evaluate the impact of current treatments, and for the clinician-scientist who is seeking to apply basic research technology and skills to understand ing and control in this disease area. This book does not attempt to cover the entire breadth of urinary malig nant disease, but focuses in depth on specific problem areas. It provides the reader with sufficient background and understanding for him to be able to evaluate future studies in the areas addressed, or even to develop his own projects. A reasonable balance has been established between clinical and basic research problems, recognizing that the two disciplines truly are not separable. The book serves to define the state of the art and, as such, will of urologic oncology.