G Protein Signaling Mechanisms in the Retina

G Protein Signaling Mechanisms in the Retina
Title G Protein Signaling Mechanisms in the Retina PDF eBook
Author Kirill A. Martemyanov
Publisher Springer
Pages 197
Release 2014-09-04
Genre Medical
ISBN 1493912186

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The main purpose of this volume is to provide a focused analysis of the function of the G protein-coupled signaling pathways that operate in the interconnected network of retinal neurons as they detect and encode the information carried by light. The organization of this volume will generally follow the path of signal flow in the retina. First we will describe recent advances in understanding the phototransduction cascade of rod and cone photoreceptors, which use signaling cascade based on the GPCR rhodopsin to transduce incident light into neural activity. Chapters will be devoted to unique specializations of the two major types of photosensitive cells that comprise the predominant input for our spatial and color vision. Subsequently, the mechanisms of synaptic information encoding by retinal ON bipolar cells will be described, where the GPCR mGluR6 plays a fundamental role. Chapters in this section will examine macromolecular organization of the mGluR6 signaling pathway as well as current understanding of its function. The functional characteristics of this signaling mechanism will be explored in detail. Additionally, this section will cover the role of dopamine receptors in modulating signal transmission between photoreceptors and ON-bipolar cells. Finally, chapters will be focused on the output neurons of the inner retina, ganglion cells, where the components of the emerging GPCR melanopsin cascade in intrinsically photosensitive ganglion cells will be detailed. Collectively these mechanisms allow the retina to represent visual space over a wide range of light intensities.

Webvision

Webvision
Title Webvision PDF eBook
Author Helga Kolb
Publisher
Pages
Release 2007
Genre
ISBN

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Molecular Biology of the Cell

Molecular Biology of the Cell
Title Molecular Biology of the Cell PDF eBook
Author
Publisher
Pages 0
Release 2002
Genre Cells
ISBN 9780815332183

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Signal Transduction in the Retina

Signal Transduction in the Retina
Title Signal Transduction in the Retina PDF eBook
Author Steven J. Fliesler
Publisher CRC Press
Pages 410
Release 2007-12-26
Genre Medical
ISBN 1420007165

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In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approache

G Protein Signaling Mechanisms in the Retina

G Protein Signaling Mechanisms in the Retina
Title G Protein Signaling Mechanisms in the Retina PDF eBook
Author Kirill Martemyanov
Publisher
Pages 208
Release 2014-09-30
Genre
ISBN 9781493912193

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Neuromorphic Olfaction

Neuromorphic Olfaction
Title Neuromorphic Olfaction PDF eBook
Author Krishna C. Persaud
Publisher CRC Press
Pages 237
Release 2016-04-19
Genre Medical
ISBN 1439871728

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Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p

Principles of Endocrinology and Hormone Action

Principles of Endocrinology and Hormone Action
Title Principles of Endocrinology and Hormone Action PDF eBook
Author Antonino Belfiore
Publisher Springer
Pages 0
Release 2018-02-08
Genre Medical
ISBN 9783319446745

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This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.