This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

"This inventive production was hatched within a mind fringed with Fumes of Formation, the Ingenious Innings of Inspiration and Thorny Tincture of Thought." Fumes of Formation is the second book of poetry by the late, great Amanda McKittrick Ros. It contains, among many equally astonishing poems, her most famous: "On Visiting Westminster Abbey" This is the first sentence: Holy Moses! Have a look! Flesh decayed in every nook! Some rare bits of brain lie here, Mortal loads of beef and beer, Some of whom are turned to dust, Every one bids lost to lust; Royal flesh so tinged with 'blue' Undergoes the same as you.

Poems of Puncture, the first book of poetry by Amanda McKittrick Ros, universally considered to be the best worst writer in the history of the English language, is here presented in its glorious entirety. Poems of Puncture contains many piercing verses spanning a broad range of themes, each clearly held great emotional importance to Amanda McKittrick Ros: a spa, her dog, her most beloved tree, and many poems devoted to people she didn't like, including "Largebones - The Lawyer" : Beneath me hear in stinking clumps, Lies Lawyer Largebones all in lumps ; A rotten mass of clockholed clay, Which grows more honeycombed each day. See how the rats have scratched his face ? Now so unlike the human race ; I very much regret I can't Assist them in their eager "bent." What the heck!?! Please Enjoy!

Ducktown Smoke