In review, the amount of information available on the morphological and func tional properties of the frog nervous system is very extensive indeed and in certain areas is the only available source of information in vertebrates. Further more, much of the now classical knowledge in neurobiology was originally ob tained and elaborated in depth in this vertebrate. To cite only a few examples, studies of nerve conduction, neuromuscular transmission, neuronal integration, sense organs, development, and locomotion have been developed with great detail in the frog and in conjunction provide the most complete holistic descrip tion of any nervous system. Added to the above considerations, the ease with which these animals may be maintained (both as adults and during development) and the advantage of their lower cost as compared with other vertebrate forms make the frog one of the most important laboratory animals in neurobiology. With these thoughts in mind, we decided to compile this volume. Our goal in doing so was to assemble as much as possible of the information available on frog neurobiology and to have the different topics covered by authorities in each of the fields represented. To keep the handbook restricted to one volume, we found it necessary to omit the large field of amphibian muscle neurobiology, which has already been summarized in various other publications.

Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely

This comprehensive reference is clearly destined to become the definitive anatomical basis for all molecular neuroscience research. The three volumes provide a complete overview and comparison of the structural organisation of all vertebrate groups, ranging from amphioxus and lamprey through fishes, amphibians and birds to mammals. This thus allows a systematic treatment of the concepts and methodology found in modern comparative neuroscience. Neuroscientists, comparative morphologists and anatomists will all benefit from: * 1,200 detailed and standardised neuroanatomical drawings * the illustrations were painstakingly hand-drawn by a team of graphic designers, specially commissioned by the authors, over a period of 25 years * functional correlations of vertebrate brains * concepts and methodology of modern comparative neuroscience * five full-colour posters giving an overview of the central nervous system of the vertebrates, ideal for mounting and display This monumental work is, and will remain, unique; the only source of such brilliant illustrations at both the macroscopic and microscopic levels.

The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.

This volume presents the proceedings of the NATO Advanced Study Institute on "Advances in Vertebrate Neuroethology" held at the University of Kassel, Federal Republic of Germany in August 1981. During the last decade much progress has been made in understanding the neurophysiological bases of behavior in both vertebrates and invertebrates. The reason for this is that a number of new physiological, anatomical, and histochemical techniques have recently been developed for brain research which can now be combined with ethological methods for the analysis of animal behavior to form a new field of research known as "Neuroethology". The term Neuroethology was originally introduced by S.L.Brown and R.W.Hunsperger (1963) in connection with studies on the activation of agonistic behaviors by electrical brain stimulation in cats. Neuroethology was more closely defined by G.Hoyle (1970) in the context of a review on cellular mechanisms underlying behavior of invertebrates. Since the 6th annual meeting of the Society for Neuroscience held in Toronto in 1976, Neuroethology has become established as a session topic.

Understanding how the brain works is undoubtedly the greatest challenge for human intelligence and one of the most ambitious goals of contemporary science. We are certainly far from this goal, but significant advancements in several fields of Neuroscience and Neurobiology are being obtained at an increasing pace. The NATO ASI School in Neurobiology, held in Erice May 2-12,1995, as the 23rd Course of the International School of Biophysics, provided an update on three basic topics: Biophysics and Molecular Biology ofIon Channels, Sensory Transduction, and Higher Order Functions. Current knowledge on these subjects was covered by formal lectures and critical discussions between lecturers and participants. This book collects original contributions from those scientists who attended the School. Many students presented their results in poster sessions, steering lively informal discussions. A selection of these contributions is also included. A major portion of the program of the School was devoted to a general overview of current trends of thought and experimental approaches in neurobiology, emphasising the importance of understanding molecular aspects of the elementary events underlying sensory transduction and processing in the nervous system, without indulging however in a pure reductionistic view of such complex phenomena. Recent studies of molecular biology and the electrophysiology of heterologously expressed ionic channels, have shed new light on the molecular mechanisms underlying ionic permeation of excitable membranes and its regulation by physical and chemical parameters.

A Laboratory Guide to Frog Anatomy is a manual that provides essential information for dissecting frogs. The selection provides comprehensive directions, along with detailed illustrations. The text covers five organ systems, namely skeletal, muscular, circulatory, urogenital, and nervous system. The manual also details a frog's major external and internal features. The book will be of great use to students and instructors of biology related laboratory course.