Our understanding of the biology of bladder cancer has advanced remarkably since the second edition of 'Fast Facts: Bladder Cancer' was published in 2006. Five new immunotherapies targeting the PD-1 axis were approved in 2016 and 2017 for the treatment of advanced bladder cancer, reflecting this transformative explosion in knowledge about the biology of the disease. This new era of targeted treatment offers hope to patients, particularly those with advanced disease. However, for clinicians it means a lot to understand in terms of how these immunotherapies are integrated into the treatment paradigm. Who they are suitable for? When are they best used? What is the optimal sequence of treatments for individual patients? This third edition of 'Fast Facts: Bladder Cancer' has been updated extensively throughout by two new authors, bringing a fresh perspective. Key updates include: • the latest understanding of pathology and biology • current standards for investigation, imaging and diagnosis • the critical role that awareness of the significance of hematuria among patients and primary care health professionals can make to earlier detection at curable stages of the disease • the roles of drugs, surgery and radiation therapy in treatment at different stages of bladder cancer, and when and how best to intervene, aided by understanding of the risk factors for disease relapse and progression • a new chapter about immunotherapy for bladder cancer • future trends in a rapidly evolving field. 'Fast Facts: Bladder Cancer' is a concise guide that will be of value to clinicians and health professionals involved in the detection and treatment of bladder cancer. This highly readable resource provides a comprehensive and current view of this complex disease, enabling informed discussions with patients. Contents: • Epidemiology and etiology • Pathology and biology • Clinical presentation • Investigations • Management of non-muscle-invasive disease • Management of muscle-invasive disease • Management of advanced and metastatic disease • Immunotherapy • Future trends • Useful resources

Early detection of renal problems coupled with the appropriate therapeutic strategy can radically reduce the progressive nature of, and complications associated with, chronic kidney disease, and in many instances will result in the successful treatment of acute kidney injury. As many patients will not be seen by nephrologists, it is essential that all healthcare professionals, in hospitals and in the community, have an awareness of renal disease – the presenting signs, differential diagnoses, treatment strategies and approach to the management of complications. 'Fast Facts: Renal Disorders' is an easy-to-read, evidence-based guide to renal diseases and disorders for all doctors, nurses and medical students. It includes: • A clear explanation of proteinuria, hematuria, electrolyte imbalances and acid–base disorders • A concise summary of kidney function tests, imaging techniques and biopsy • Important questions for prompt diagnosis of acute kidney injury • Management options for chronic kidney disease and its complications • Practical guidance on the most common renal problems, including glomerulonephritis, systemic disease, UTIs and kidney stones Written by three specialists of international repute, 'Fast Facts: Renal Disorders' provides the key information required for the optimal care of renal patients. This fully updated second edition will help healthcare professionals assess, identify, treat and refer patients with renal problems appropriately. Directly applicable to the clinical setting, it is essential reading for all primary care providers, junior hospital doctors, specialist trainees, renal nurses and medical students. Contents: • Proteinuria, hematuria and renal investigations • Electrolyte disturbances and acid–base disorders • Acute kidney injury • Chronic kidney disease • Hypertension and diabetic nephropathy • Glomerulonephritis • Systemic disease • Inherited kidney disease • Urinary tract infection • Kidney stones • Urinary tract obstruction and tumors • Renal replacement therapy and transplantation

Most men with BPH can be diagnosed and managed in the primary care setting. In choosing appropriate treatment, clinicians must take into account not only the nature and severity of symptoms but also the preferences of the patient and his immediate family, cost–benefit considerations and long-term effectiveness of therapy. Written by two leading urologists, 'Fast Facts: Benign Prostatic Hyperplasia' provides a refreshingly readable, practical overview of the pathophysiology, diagnosis and treatment of BPH including: • Use of DRE and PSA results to discriminate between prostate cancer and BPH • An evidence-based review of the latest medical therapies • A concise overview of the surgical and minimally invasive treatment options • When to refer to a urologist There is important work to do to raise awareness of men’s health issues in general and the problem of BPH in particular. Lower urinary tract symptoms are among the commonest reasons for a man to consult his doctor, and this ever-popular book – the first 7th edition in the Fast Facts series – remains a must-read for all primary care providers. Contents: • Pathophysiology • Diagnosis • Medical management • Traditional surgical treatment options • Minimally invasive treatment options • Considerations in treatment decisions • Issues in BPH • Useful resources

When it comes to detecting, diagnosing and treating women who have, or are suspected of having, ovarian cancer, there are significant opportunities for well-informed healthcare professionals to intervene in a meaningful way. 'Fast Facts: Ovarian Cancer' examines the areas that will have the biggest effect in clinical practice, including: • the evidence for and against screening • the valuable role of genetic testing in identifying at-risk women • if and when to operate • strategies to overcome platinum resistance • the impact of targeted therapies. From the tools that will help establish a swift diagnosis to the risks and benefits of palliative salvage surgery, this refreshingly readable resource captures the key knowledge that every busy healthcare professional needs in order to make better health decisions for patients with ovarian cancer. Contents: • Epidemiology and prevention • Pathophysiology and classification • Genetic testing • Diagnosis, staging and grading • Surgery • Chemotherapy • Recurrent ovarian cancer • Targeted therapies • Non-epithelial ovarian cancers • Follow-up and palliative surgery • Useful resources

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This is the tenth edition of this Fast Facts handbook since the first was published in 1996 – the many iterations are testament to the rapid changes in the field and steadily improving outlook for patients. This new edition introduces the Gleason grade grouping (Chapter 1), which has important prognostic value, and nomograms that are used to evaluate risk (Chapter 3). Our understanding of the genetics and underlying pathogenesis of prostate cancer is growing apace, leading to the identification of germline mutations and the development of genomic tests to help identify and direct therapy for those at greatest risk of developing clinically significant disease. They also provide reassurance for those patients who have opted for active surveillance (Chapters 3 and 5). Imaging techniques are also improving rapidly, particularly multiparametric MRI (Chapter 4). As this book is concise, fully up to date and evidence based, we believe it is an ideal resource for those general urologists, primary care providers, specialist nurses, trainees and allied healthcare professionals who want to get quickly up to speed in this fast-moving and ever-expanding field. Contents: • Epidemiology and pathophysiology • Diet, lifestyle and chemoprevention • Screening and early detection • Diagnosis, staging and prognostic indicators • Management of clinically localized disease • Managing recurrence after initial therapy • Managing metastatic hormone-sensitive prostate cancer • Management of castrate-resistant prostate cancer • Survivorship and management of treatment-related side effects and complications

All health professionals, regardless of specialty, will care for patients with pain that has persisted for more than 6 months. This fully updated fourth edition of 'Fast Facts: Chronic and Cancer Pain', written by two internationally renowned experts in the field, is designed to bring busy health professionals up to speed with the latest information in this area, including: • Easy-to-read overviews of pain mechanisms • A practical approach to pain assessment • Developments in stepped care and multimodal management • The latest thinking on opioids With health services around the world responding to calls to improve the management of painful long-term conditions, develop preventive and cost-effective solutions, and respond to patient choice and voice, this easy-to-read fact-packed book is essential reading for all GPs, nurses, junior hospital doctors, physical therapists, clinical psychologists, occupational therapists, pharmacists, medical specialists and medical students wanting - and needing - to know more. Contents: • Definitions and mechanisms • Assessment of pain • Treatment options • Trigeminal neuralgia • Complex regional pain syndrome • Diabetic and postherpetic neuropathic pain Central pain • Persistent postsurgical pain • Cancer pain • Musculoskeletal pain • Visceral pain • Headache