Exploring Molecular Targets to Treat Neurodegenerative Disorders
Title | Exploring Molecular Targets to Treat Neurodegenerative Disorders PDF eBook |
Author | Prashant Tiwari |
Publisher | Cambridge Scholars Publishing |
Pages | 326 |
Release | 2024-05-01 |
Genre | Medical |
ISBN | 1036404773 |
This book delves into the delicate realm of neurodegenerative illnesses, navigating the vast landscape of molecular targets with care and purpose. Researchers are studying the complex pathways involved in diseases such as Alzheimer’s, Parkinson’s, and Huntington’s in order to identify specific molecules that could be targeted for therapy. The present work explores potential methods of intervention by carefully analysing neural circuits, protein misfolding, and genetic predispositions, unravelling the complexities of the human mind by focusing on individual molecular targets. As new findings emerge, reducing the severe consequences of neurodegenerative illnesses becomes increasingly possible, providing optimism for millions of people throughout the world.
Disease-Modifying Targets in Neurodegenerative Disorders
Title | Disease-Modifying Targets in Neurodegenerative Disorders PDF eBook |
Author | Veerle Baekelandt |
Publisher | Academic Press |
Pages | 324 |
Release | 2017-03-31 |
Genre | Medical |
ISBN | 012805266X |
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress Summarizes how patients are treated today, providing a glance at future disease management Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists Written and peer reviewed by outstanding scientists in their respective fields
The Molecular and Cellular Basis of Neurodegenerative Diseases
Title | The Molecular and Cellular Basis of Neurodegenerative Diseases PDF eBook |
Author | Michael S. Wolfe |
Publisher | Academic Press |
Pages | 561 |
Release | 2018-03-29 |
Genre | Medical |
ISBN | 0128113057 |
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts
Neurodegeneration
Title | Neurodegeneration PDF eBook |
Author | Forum on Neuroscience and Nervous System Disorders |
Publisher | National Academies Press |
Pages | 0 |
Release | 2013-12-26 |
Genre | Medical |
ISBN | 9780309285674 |
Neurodegeneration: Exploring Commonalities Across Diseases is the summary of a workshop hosted by the Institute of Medicine\'s (IOM\'s) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Participants from academia; pharmaceutical and biotechnology industries; government agencies such as the National Institutes of Health and the U.S. Department of Veterans Affairs (VA); patient advocacy groups; and private foundations presented and identified potential opportunities for collaboration across the respective research and development communities. This report identifies and discusses commonalities related to genetic and cellular mechanisms, identifies areas of fundamental science needed to facilitate therapeutics development, and explores areas of potential collaboration among the respective research communities. Neurodegenerative diseases, such as Alzheimer\'s disease, Parkinson\'s disease, ALS, and FTD, are becoming increasingly prevalent in the United States due to an aging population. Implications are grave for quality of life and health care costs. Research on neurodegenerative diseases has expanded greatly over the past four decades. Nevertheless, fundamental questions remain about the biology of these diseases, and further insights into the mechanisms of these diseases would help to inform the development of effective means to prevent and to efficiently treat them. Recent findings have revealed certain commonalities in genetic and cellular mechanisms across neurodegenerative diseases. These findings suggest that it might be valuable - at least in some cases - to change the traditional way of studying these diseases by no longer seeing each as an independent entity, but rather as clinical variants of common cellular and molecular biological defects. This approach could help enhance basic scientific understanding of neurodegenerative disease, and could help with the development of biomarkers and new therapeutics.
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
Title | Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders PDF eBook |
Author | Adeboye Adejare |
Publisher | Academic Press |
Pages | 310 |
Release | 2016-09-20 |
Genre | Medical |
ISBN | 0128028114 |
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource
Neurodegenerative Diseases
Title | Neurodegenerative Diseases PDF eBook |
Author | Raymond Chuen-Chung Chang |
Publisher | BoD – Books on Demand |
Pages | 574 |
Release | 2011-12-09 |
Genre | Medical |
ISBN | 953307485X |
Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring focuses on biological mechanisms, prevention, neuroprotection and even monitoring of disease progression. This book emphasizes the general biological processes of neurodegeneration in different neurodegenerative diseases. Although the primary etiology for different neurodegenerative diseases is different, there is a high level of similarity in the disease processes. The first three sections introduce how toxic proteins, intracellular calcium and oxidative stress affect different biological signaling pathways or molecular machineries to inform neurons to undergo degeneration. A section discusses how neighboring glial cells modulate or promote neurodegeneration. In the next section an evaluation is given of how hormonal and metabolic control modulate disease progression, which is followed by a section exploring some preventive methods using natural products and new pharmacological targets. We also explore how medical devices facilitate patient monitoring. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
Metal-based Neurodegeneration
Title | Metal-based Neurodegeneration PDF eBook |
Author | Robert Crichton |
Publisher | John Wiley & Sons |
Pages | 240 |
Release | 2006-05-01 |
Genre | Medical |
ISBN | 0470022566 |
This exciting new book opens a window into the causes ofdebilitating neurological disorders such as Parkinson’sdisease, CJD and Huntington’s disease, and gives indicationsof the prospects for therapy, based on the understanding ofmolecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the bookoutlines the role of metals in human biology, in particular in thebrain and explores tools for testing potential therapeuticstrategies. It concludes with an overview of the potential of bothchelation and antioxidant therapy and outlines some perspectivesfor the future.