Despite constant significant advances, cardiovascular as well as more general outcomes of hemodialysis treatment remain unsatisfactory. The introduction of innovative 'high retention onset' membranes has led to the development of a new treatment modality called 'expanded hemodialysis' (HDx), which is the focus of this book. This new therapy is likely to benefit end-stage kidney disease patients, thanks to enhanced removal of molecules retained by current dialysis techniques. HDx is simple to set up and application does not require special hardware or specific nursing skills. This book contains emerging evidence and fascinating new hypotheses on HDx. It is highly recommended for all physicians and healthcare professionals who are caring for dialysis patients and are seeking innovation and improved care solutions. It will also be of considerable interest to students and fellows.

**Selected for Doody's Core Titles® 2024 in Transplantation Surgery** From basic science to practical clinical tools, Chronic Kidney Disease, Dialysis, and Transplantation, 4th Edition provides you with the up-to-date, authoritative guidance you need to safely and effectively manage patients with chronic renal disease. Covering all relevant clinical management issues, this companion volume to Brenner and Rector's The Kidney presents the knowledge and expertise of renowned researchers and clinicians in the fields of hemodialysis, peritoneal dialysis, critical care nephrology, and transplantation – for an all-in-one, indispensable guide to every aspect of this fast-changing field. - Contains expanded content on economics and outcomes of treatment, as well as acute kidney injury. - Covers hot topics such as the genetic causes of chronic kidney disease, ethical challenges and palliative care, and home hemodialysis. - Discusses the latest advances in hypertensive kidney disease, vitamin D deficiency, diabetes management, transplantation, and more. - Provides a clear visual understanding of complex information with high-quality line drawings, photographs, and diagnostic and treatment algorithms. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

On-line HDF represents a major technical development in the delivery of hemodialysis therapy: It combines the properties of increased diffusion available in current high-flux membranes with convective removal of between 6 and 30 liters per treatment and requires the use of ultrapure water and online filtration of replacement fluid. On-line HDF has been successfully introduced in Europe and Asia and is routinely prescribed for dialysis patients in these regions.The book at hand summarizes the history and achievements of on-line HDF in four parts: A report of the technological development in both machine and fiber/dialyzer is followed by a description of the challenges encountered in the evolution of on-line HDF, collecting the accounts of clinical key opinion leaders who had been involved in its early application. The third part presents a comprehensive review of the clinical results achieved with on-line HDF from its inception to the present times, in which it represents the clinical golden standard. The fourth and final part is dedicated to on-line HDF as a ‘vision’ for the future.

Hemodialysis (HD) is the commonest form of kidney replacement therapy worldwide with a prevalence rate close to 90%. Despite significant improvements in HD techniques and related devices and solutions, the cardiovascular and all-cause mortality of HD patients remains unacceptably elevated. More recently, there have been significant improvements in the creation and maintenance of vascular access as well as the knowledge of types, classification, and monitoring of uremic toxins and their relationship with inflammation, atherosclerosis and vascular classification, and cardiovascular and all-cause mortality. More interesting is the innovation in dialysis membranes/dialyzers, which resulted in the creation of the medium cut-off membrane, which enables the safe, simple, and effective removal of middle- and large-sized uremic toxins. This type of HD treatment is called expanded hemodialysis (HDx) therapy, which so far has resulted in significant improvement in the quality of life of HD patients as well as reductions in hospitalization, medications, and non-fatal cardiovascular events. Updates on Hemodialysis discusses these innovations and how they can be used to improve daily practice and achieve the best possible medical outcomes in HD patients.

The revised, updated Fourth Edition of this popular handbook provides practical, accessible information on all aspects of dialysis, with emphasis on day-to-day management of patients. Chapters provide complete coverage of hemodialysis, peritoneal dialysis, special problems in dialysis patients, and problems pertaining to various organ systems. This edition reflects the latest guidelines of the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) on hemodialysis and peritoneal dialysis adequacy and on nutrition. New chapters cover chronic kidney disease management in predialysis patients, frequent daily or nocturnal hemodialysis, and hemodiafiltration. Chapters on venous and arteriovenous access have been completely revised. Each chapter provides references to relevant Web sites.

A comprehensive summary of high-flux dialyzers and their properties Dialyzers today are developed with high permeability and biocompatibility in mind, even though the definition of these so- called high-flux dialyzers remains controversial. In the Japanese reimbursement system, dialyzers are divided into five types, ranging from I to V, in accordance with their clearance for beta2- microglobulin (beta2-MG). Classes IV and V (beta2-MG clearance greater or equal to 50 and 70 ml/min, respectively, at a blood flow rate of 200 ml/min) are the most common ones, used in more than 90% of Japanese dialysis patients. Membranes used in types IV and V dialyzers are called high-performance membranes (HPMs) and are characterized by an exceptionally high flux rate, permeability and biocompatibility. The book at hand covers all aspects of these HPM dialyzers, including their definitions and characteristics, clinical experiences and basic investigations. Moreover, historical HPMs and several membranes with special characteristics that are not categorized into classes IV or V are discussed. Providing a summary of commercially available HPM dialyzers, this publication not only serves as a textbook for those interested in state-of the-art dialysis treatment, but is also a concise database of the products available.