Like engineering systems, biological systems must also operate effectively in the presence of internal and external uncertainty—such as genetic mutations or temperature changes, for example. It is not surprising, then, that evolution has resulted in the widespread use of feedback, and research in systems biology over the past decade has shown that feedback control systems are widely found in biology. As an increasing number of researchers in the life sciences become interested in control-theoretic ideas such as feedback, stability, noise and disturbance attenuation, and robustness, there is a need for a text that explains feedback control as it applies to biological systems. Written by established researchers in both control engineering and systems biology, Feedback Control in Systems Biology explains how feedback control concepts can be applied to systems biology. Filling the need for a text on control theory for systems biologists, it provides an overview of relevant ideas and methods from control engineering and illustrates their application to the analysis of biological systems with case studies in cellular and molecular biology. Control Theory for Systems Biologists The book focuses on the fundamental concepts used to analyze the effects of feedback in biological control systems, rather than the control system design methods that form the core of most control textbooks. In addition, the authors do not assume that readers are familiar with control theory. They focus on "control applications" such as metabolic and gene-regulatory networks rather than aircraft, robots, or engines, and on mathematical models derived from classical reaction kinetics rather than classical mechanics. Another significant feature of the book is that it discusses nonlinear systems, an understanding of which is crucial for systems biologists because of the highly nonlinear nature of biological systems. The authors cover tools and techniques for the analysis of linear and nonlinear systems; negative and positive feedback; robustness analysis methods; techniques for the reverse-engineering of biological interaction networks; and the analysis of stochastic biological control systems. They also identify new research directions for control theory inspired by the dynamic characteristics of biological systems. A valuable reference for researchers, this text offers a sound starting point for scientists entering this fascinating and rapidly developing field.

This comprehensive, detailed reference provides readers with both a working knowledge of Mathematica in general and a detailed knowledge of the key aspects needed to create the fastest, shortest, and most elegant implementations possible. It gives users a deeper understanding of Mathematica by instructive implementations, explanations, and examples from a range of disciplines at varying levels of complexity. The three volumes -- Programming, Graphics, and Mathematics, total 3,000 pages and contain more than 15,000 Mathematica inputs, over 1,500 graphics, 4,000+ references, and more than 500 exercises. This first volume begins with the structure of Mathematica expressions, the syntax of Mathematica, its programming, graphic, numeric and symbolic capabilities. It then covers the hierarchical construction of objects out of symbolic expressions, the definition of functions, the recognition of patterns and their efficient application, program flows and program structuring, and the manipulation of lists. An indispensible resource for students, researchers and professionals in mathematics, the sciences, and engineering.

In their 1909 publication Théorie des corps déformables, Eugène and François Cosserat made a historic contribution to materials science by establishing the fundamental principles of the mechanics of generalized continua. The chapters collected in this volume showcase the many areas of continuum mechanics that grew out of the foundational work of the Cosserat brothers. The included contributions provide a detailed survey of the most recent theoretical developments in the field of generalized continuum mechanics and can serve as a useful reference for graduate students and researchers in mechanical engineering, materials science, applied physics and applied mathematics.

An up-to-date account of algebraic statistics and information geometry, which also explores the emerging connections between these two disciplines.