Published more than three decades after Rachel Carson's Silent Spring warned of the impact of chemicals on the environment, this book offers a critique of current thinking on cancer and its causes. It argues that the evidence has been wilfully ignored, and that the environment is still being poisoned. Throughout her study, the author weaves two stories - of Rachel Carson and her battle to be heard and of her own cancer of the bladder, which she traces back to agricultural and industrial contamination.

downstream: reimagining water brings together artists, writers, scientists, scholars, environmentalists, and activists who understand that our shared human need for clean water is crucial to building peace and good relationships with one another and the planet. This book explores the key roles that culture, arts, and the humanities play in supporting healthy water-based ecology and provides local, global, and Indigenous perspectives on water that help to guide our societies in a time of global warming. The contributions range from practical to visionary, and each of the four sections closes with a poem to encourage personal freedom along with collective care. This book contributes to the formation of an intergenerational, culturally inclusive, participatory water ethic. Such an ethic arises from intellectual courage, spiritual responsibilities, practical knowledge, and deep appreciation for human dependence on water for a meaningful quality of life. Downstream illuminates how water teaches us interdependence with other humans and living creatures, both near and far.

Contains essays that explore non-reciprocated relationships with regard to the environment. This work includes contributions that discuss moral issues that arise when decisions by individuals, corporations, or governments cause changes in the environment that affect those who do not participate in the decisions.

Sandra Steingraber, biologist, poet, and survivor of cancer in her twenties, brings all three perspectives to bear on the most important health and human rights issue of our time: the growing body of evidence linking cancer to environmental contaminations. Her scrupulously researched scientific analysis ranges from the alarming worldwide patterns of cancer incidence to the sabotage wrought by cancer-promoting substances on the intricate workings of human cells. In a gripping personal narrative, she travels from hospital waiting rooms to hazardous waste sites and from farmhouse kitchens to incinerator hearings, bringing to life stories of communities in her hometown and around the country as they confront decades of industrial and agricultural recklessness. Living Downstream is the first book to bring together toxics-release data -- now finally made available through under the right-to-know laws -- and newly released cancer registry data. Sandra Steingraber is also the first to trace with such compelling precision the entire web of connections between our bodies and the ecological world in which we eat, drink, breathe, and work. Her book strikes a hopeful note throughout, for, while we can do little to alter our genetic inheritance, we can do a great deal to eliminate the environmental contributions to cancer, and she shows us where to begin. Living Downstream is for all readers who care about the health of their families and future generations. Sandra Steingraber's brave, clear, and careful voice is certain to break the paralyzing silence on this subject that persists more than three decades after Rachel Carson's great early warning.

DOWNSTREAM INDUSTRIAL BIOTECHNOLOGY An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley’s Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biopharmaceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.