Soon to be an Apple TV+ series starring Cate Blanchett and Kevin Kline “Disclaimer is something special. . . an outstandingly clever and twisty tale that’s been perfectly engineered to make heads spin.” — Janet Maslin, New York Times A brilliantly conceived, deeply unsettling psychological thriller about a woman haunted by secrets, the consuming desire for revenge, and the terrible price we pay when we try to hide the truth. What if you realized the terrifying book you were reading was all about you? When a mysterious novel appears at documentary filmmaker Catherine Ravenscroft’s bedside, she is curious. She has no idea who might have sent her The Perfect Stranger—or how it ended up on her nightstand. At first, she is intrigued by the suspenseful story that unfolds. And then she realizes this isn’t fiction. The Perfect Stranger re-creates in vivid, unmistakable detail the day Catherine became hostage to a dark secret, a secret that only one other person knew—and that person is dead. Now that the past Catherine so desperately wants to forget is catching up with her, her world is falling apart. Plunged into a living nightmare, her only hope is to confront what really happened on that awful day . . . even if the shocking truth might destroy her.

Advances in medical, biomedical and health services research have reduced the level of uncertainty in clinical practice. Clinical practice guidelines (CPGs) complement this progress by establishing standards of care backed by strong scientific evidence. CPGs are statements that include recommendations intended to optimize patient care. These statements are informed by a systematic review of evidence and an assessment of the benefits and costs of alternative care options. Clinical Practice Guidelines We Can Trust examines the current state of clinical practice guidelines and how they can be improved to enhance healthcare quality and patient outcomes. Clinical practice guidelines now are ubiquitous in our healthcare system. The Guidelines International Network (GIN) database currently lists more than 3,700 guidelines from 39 countries. Developing guidelines presents a number of challenges including lack of transparent methodological practices, difficulty reconciling conflicting guidelines, and conflicts of interest. Clinical Practice Guidelines We Can Trust explores questions surrounding the quality of CPG development processes and the establishment of standards. It proposes eight standards for developing trustworthy clinical practice guidelines emphasizing transparency; management of conflict of interest ; systematic review-guideline development intersection; establishing evidence foundations for and rating strength of guideline recommendations; articulation of recommendations; external review; and updating. Clinical Practice Guidelines We Can Trust shows how clinical practice guidelines can enhance clinician and patient decision-making by translating complex scientific research findings into recommendations for clinical practice that are relevant to the individual patient encounter, instead of implementing a one size fits all approach to patient care. This book contains information directly related to the work of the Agency for Healthcare Research and Quality (AHRQ), as well as various Congressional staff and policymakers. It is a vital resource for medical specialty societies, disease advocacy groups, health professionals, private and international organizations that develop or use clinical practice guidelines, consumers, clinicians, and payers.

Prior to 1862, when the Department of Agriculture was established, the report on agriculture was prepared and published by the Commissioner of Patents, and forms volume or part of volume, of his annual reports, the first being that of 1840. Cf. Checklist of public documents ... Washington, 1895, p. 148.