In this book, experts in the field discuss the latest research in developmental neuroendocrinology. Given that the hypothalamus is the center of neuroendocrine activity, the reader will learn about the molecular specification of hypothalamic cells, developmental modulators and epigenetic factors influencing hypothalamic development, and the development of neuroendocrine circuits. Each chapter provides a concise review of the current and future perspectives in developmental neuroendocrinology. Important insights into state-of-the-art techniques applied to functional circuit tracking, lineage tracing of hypothalamic cells, and the identification of genes altered through epigenetic mechanisms are also provided. Given its scope, the book will appeal to all students and researchers who are eager to understand the processes involved in hypothalamus development and the establishment of neuroendocrine circuits. This is the ninth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series* that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. *Volumes 1-7 published by Wiley.

Model Animals in Neuroendocrinology: From Worm to Mouse to Man offers a masterclass on the opportunities that different model animals offer to the basic understanding of neuroendocrine functions and mechanisms of action and the implications of this understanding. The authors review recent advances in the field emanating from studies involving a variety of animal models, molecular genetics, imaging technologies, and behavior assays. These studies helped unravel mechanisms underlying the development and function of neuroendocrine systems. The book highlights how studies in a variety of model animals, including, invertebrates, fish, birds, rodents and mammals has contributed to our understanding of neuroendocrinology. Model Animals in Neuroendocrinology provides students, scientists and practitioners with a contemporary account of what can be learnt about the functions of neuroendocrine systems from studies across animal taxonomy. This is the seventh volume in the Masterclass in Neuroendocrinology Series, a co-publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.

In this book, experts in the field provide comprehensive descriptions of the neuroanatomy of the hypothalamic neuroendocrine systems. The book begins with an extensive discussion on the structural components of the neuroendocrine systems. The reader will be introduced to the anatomy and biology of the hypothalamus and the pituitary. The human hypothalamus is presented in particular detail using state-of-the-art imaging techniques. In the next section, the neuroanatomy of traditional hypothalamo-hypophyseal systems is highlighted, with chapters describing magnocellular neuroendocrine cells and discussing the respective types of hypothalamic neurons that regulate various pituitary hormones. Following this detailed structural and anatomical description of the neuroendocrine system, the book’s final section focuses on the hypothalamic control of neuroendocrine functions. This includes the control of circadian rhythm, metabolism and appetite via specific peptidergic circuits. This book provides essential information on the neuroanatomy and control of neuroendocrine systems, addresses cutting-edge research questions posed by recent advances in the development of potent neuroanatomical tools, and highlights the latest technologies used in neuroendocrinology research, making it a valuable reference guide for students, trainees and established researchers alike. This is the twelfth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and to encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Chapter 12 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com

Receptors for cell hormones, growth factors, Fourth, alterations in the development of neu and neurotransmitters are involved in the ral receptors may have profound implications control and modulation of an enormous array for the structure and function of the of biological processes. The development of organism. As much as possible, the reper these receptors has distinct spatial and tem cussions of disrupting the orchestration of poral arrangements, and alterations in this receptor development in the nervous system pattern during embryogenesis can have signi are discussed. In many instances, however, ficant consequences for the well-being of the we are just beginning to learn about some fetus, infant, child and adult. The developing receptors and the authors may not be in a nervous system is particularly dependent on position to discuss the consequences of recep receptors because its period of structural and tor dysfunction. functional organization extends through both In designing these two volumes, we have prenatal and postnatal phases. Moreover, asked major figures in each field to review the receptors are a key element in neural com literature, to apprise the audience of their munication in both the developing and adult latest findings, and to provide a perspective on organism, so that the ontogeny of receptors is the role of receptors in the developing nervous crucial in determining the myriad connections system. These books are intended to sum forming the circuitry of the nervous system.

Apply the latest advances in management of neuroendocrine and pituitary disorders with the Endocrinology: Adult and Pediatric: Neuroendocrinology and The Pituitary Gland eBook! Brought to you by the same expert endocrinologists responsible for the highly acclaimed two-volume Endocrinology clinical reference, this endocrinology eBook puts all of the newest latest know-how of the Pituitary Gland and Neuroendocrinology at your fingertips, instantly accessible on your favorite eReader - so you can offer your patients the best care. - Stay abreast of the newest knowledge on neuroendocrinology and the pituitary gland, including our most recent understanding of the fundamental cellular and physiologic functions of the neuroendocrine system, mechanisms underlying clinical disorders, and approaches to managing patients harboring disorders of the hypothalamus and pituitary gland. - Approach any subject either by specific gland or through a discussion of multi-hormonal integration of endocrine function, as led by the "master conductor of the endocrine orchestra," the pituitary gland. - Gain a state-of-the-art understanding of comprehensive descriptors, integrating endocrine cell ontogeny, hormonal control of growth and maturation processes, and childhood and young adult pathophysiology with maturation and aging processes. - Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and DeGroot, the go-to medical reference for endocrinologists worldwide. - Make the best clinical endocrinology decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.

Each year thousands of biomedical and behavioral researchers submit grant applications to the United States Public Health Service (USPHS) for support of their research or research training activities. The majority of these applications are submitted to the National Institutes of Health (NIH). By describing the inner workings of the NIH extramural programs and providing practical information about grant programs and processes, this authoritative work is designed to help investigators gain a more favorable edge in obtaining support for their research proposals. It offers practical insights into a broad spectrum of the basic and clinical research interests of the 21 NIH research granting components, and identifies the various mechanisms of support. Descriptions, guidance, and advice are also provided on specific areas such as how to prepare a grant application; the peer review system, the procedures leading to award decisions, the responsibilities of the NIH staff in managing the review and referral of applications, and managing grant programs. Other extramural policies and procedures are covered such as the appeals system, animal welfare, the privacy act, and research involving human subjects. Legislation, funding, and the NIH budget are also discussed. Written by two former senior-level managers at the National Institutes of Health and current consultants to several USPHS agencies, ^IA Guide to NIH Grant Programs^R is a valuable reference source for members of the biomedical and behavioral research community.