This book presents the main concepts, state of the art, advances, and case studies of fault detection, diagnosis, and prognosis. This topic is a critical variable in industry to reach and maintain competitiveness. Therefore, proper management of the corrective, predictive, and preventive politics in any industry is required. This book complements other subdisciplines such as economics, finance, marketing, decision and risk analysis, engineering, etc. The book presents real case studies in multiple disciplines. It considers the main topics using prognostic and subdiscipline techniques. It is essential to link these topics with the areas of finance, scheduling, resources, downtime, etc. to increase productivity, profitability, maintainability, reliability, safety, and availability, and reduce costs and downtime. Advances in mathematics, modeling, computational techniques, dynamic analysis, etc. are employed analytically. Computational techniques, dynamic analysis, probabilistic methods, and mathematical optimization techniques are expertly blended to support the analysis of prognostic problems with defined constraints and requirements. The book is intended for graduate students and professionals in industrial engineering, business administration, industrial organization, operations management, applied microeconomics, and the decisions sciences, either studying maintenance or needing to solve large, specific, and complex maintenance management problems as part of their jobs. The work will also be of interest to researches from academia.

Fault Diagnosis and Prognosis Techniques for Complex Engineering Systems gives a systematic description of the many facets of envisaging, designing, implementing, and experimentally exploring emerging trends in fault diagnosis and failure prognosis in mechanical, electrical, hydraulic and biomedical systems. The book is devoted to the development of mathematical methodologies for fault diagnosis and isolation, fault tolerant control, and failure prognosis problems of engineering systems. Sections present new techniques in reliability modeling, reliability analysis, reliability design, fault and failure detection, signal processing, and fault tolerant control of engineering systems. Sections focus on the development of mathematical methodologies for diagnosis and prognosis of faults or failures, providing a unified platform for understanding and applicability of advanced diagnosis and prognosis methodologies for improving reliability purposes in both theory and practice, such as vehicles, manufacturing systems, circuits, flights, biomedical systems. This book will be a valuable resource for different groups of readers - mechanical engineers working on vehicle systems, electrical engineers working on rotary machinery systems, control engineers working on fault detection systems, mathematicians and physician working on complex dynamics, and many more. Presents recent advances of theory, technological aspects, and applications of advanced diagnosis and prognosis methodologies in engineering applications Provides a series of the latest results, including fault detection, isolation, fault tolerant control, failure prognosis of components, and more Gives numerical and simulation results in each chapter to reflect engineering practices

Over the past 20 years, public concerns have grown in response to the apparent rising prevalence of food allergy and related atopic conditions, such as eczema. Although evidence on the true prevalence of food allergy is complicated by insufficient or inconsistent data and studies with variable methodologies, many health care experts who care for patients agree that a real increase in food allergy has occurred and that it is unlikely to be due simply to an increase in awareness and better tools for diagnosis. Many stakeholders are concerned about these increases, including the general public, policy makers, regulatory agencies, the food industry, scientists, clinicians, and especially families of children and young people suffering from food allergy. At the present time, however, despite a mounting body of data on the prevalence, health consequences, and associated costs of food allergy, this chronic disease has not garnered the level of societal attention that it warrants. Moreover, for patients and families at risk, recommendations and guidelines have not been clear about preventing exposure or the onset of reactions or for managing this disease. Finding a Path to Safety in Food Allergy examines critical issues related to food allergy, including the prevalence and severity of food allergy and its impact on affected individuals, families, and communities; and current understanding of food allergy as a disease, and in diagnostics, treatments, prevention, and public policy. This report seeks to: clarify the nature of the disease, its causes, and its current management; highlight gaps in knowledge; encourage the implementation of management tools at many levels and among many stakeholders; and delineate a roadmap to safety for those who have, or are at risk of developing, food allergy, as well as for others in society who are responsible for public health.

Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.

This work provides a thought-provoking account of how medical treatments can be tested with unbiased or 'fair' trials and explains how patients can work with doctors to achieve this vital goal. It spans the gamut of therapy from mastectomy to thalidomide and explores a vast range of case studies.

A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.