Structure and reactivity of phenolic compounds. Isolation and identification of phenolic compounds in biological materials. The natural distribution of the phenolic aglycones. Phenolic glycosides and their natural distribution. The genetics of phenolic compounds. Metabolism of phenolics in animals. Metabolism of phenolics in higher plants and micro-organisms. Major pathways of biosynthesis of phenols. Lignin and tannin biosynthesis. Enzymology of phenolic biosynthesis. Physiological studies on phenolic biosynthesis. The physiology and pharmacology of phenolic compounds in animals. Pathological function of phenolic compounds in plants. Relations between the taste and structure of some phenolic glycosides.

1. Catalytic hydrogenation and dehydrogenation 1; 2. Metal hydride reductions and related reactions 45; 3. Dissolving metal reductions and related reactions 145; 4. Reductions with hydrazine and its derivatives 228; 5. Oxidations with chromium and manganese compounds 257; 6. Oxidation with peracids and other peroxides 292; 7. Other methods of oxidation 353; 8. Halogenation 422; 9. The alkylation of active methylene compounds 492; 10. The aldol condensation and related reactions 629; 11. Acylation at carbon 734.

For centuries it has been recognized that plants relate to human health and well-being in many ways beyond their fundamental role as primary sources of food and energy. Many of the unique plant constituents have pronounced effects on animal systems or in the human body; some of them are potentially harmful and represent a risk in the use of a parttcular plant or in the exposure to it, others are useful as medicinal agents in the treatment of diseases. Many of the latter are extracted from plant materials on a large scale for marketing as drugs and even more of them have served as structural prototypes which inspired chemists to synthesize analog drugs with even more desirable properties. Clearly, today's drug therapy had its origins in the explora tion and exploitation of pharmacologically active plant con stituents. It is therefore appropriate that a symposium of the Phytochemical Society of tlorth America \'1as devoted to this subject. The present volume consists of eleven rapers dealing with various aspects of the topic "Phytochemistry as Related to Disease and Medicine", which were presented at the Four teenth Annual Meeting of the Phytochemical Society of tlorth America held tn August 1974 at Hestern Carol ina University in Cullowhee, N.C. Plant hallucinogens are the subject of the first three chapters. The first, by Schultes, reviews the occurrence of hallucinogenic agents in plants, in tabular form. Emphasis is on plants from Central and South America.