Concise Guide to Drug Interaction Principles for Medical Practice

Concise Guide to Drug Interaction Principles for Medical Practice
Title Concise Guide to Drug Interaction Principles for Medical Practice PDF eBook
Author Kelly L. Cozza
Publisher American Psychiatric Publishing
Pages 564
Release 2003
Genre Medical
ISBN

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An understanding of drug interactions has become essential to the practice of medicine. Since publication of the first edition of this Concise Guide in 2001, our increasing pharmacopoeia—coupled with prolonged human life spans—has made polypharmacy commonplace. Like the first edition of this unique pocket reference, the Second Edition is written expressly for clinicians. With four new contributors, this bestseller includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive Web site references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, prescribing guidelines, and medicolegal issues. This exceptionally practical guide is divided into four parts: 1. An easy-to-read, succinct review of pharmacology, written with clinicians in mind, explaining the importance of understanding our metabolic system and pharmacokinetics and P-glycoprotein drug interactions. 2. Thorough, carefully referenced reviews of the most clinically relevant phase I and phase II metabolic enzymes highlighted with newly expanded tables and study cases. 3. A section unique to this book on drug interactions by medical specialty, with drug tables arranged by how they are used in specialties such as gynecology, infectious diseases, internal medicine, neurology, oncology, psychiatry, and pain medicine. 4. Chapters on practical matters: prescribing guidelines, how to identify drug interaction patterns, strategies for reviewing the current literature, and medicolegal concerns. Enhanced by detailed descriptions and clinically based explanations, and complemented by a unique pocket guide to the most common and potent inhibitors and inducers of drug metabolism, this updated concise "how-to" guide will prove indispensable for busy students, teachers, and practitioners in all medically specialties.

Clinical Manual of Drug Interaction Principles for Medical Practice

Clinical Manual of Drug Interaction Principles for Medical Practice
Title Clinical Manual of Drug Interaction Principles for Medical Practice PDF eBook
Author Gary H. Wynn
Publisher American Psychiatric Pub
Pages 608
Release 2009-06-03
Genre Medical
ISBN 1585628921

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Drug interactions have become a significant iatrogenic complication, with as many as 5% of hospitalizations and 7,000 deaths annually attributable to drug-drug interactions in the United States. There are several reasons these numbers have increased. First, many new medications have been brought to market in recent years. Second, advances in medical care have resulted in increased longevity and more elderly patients than ever before -- patients who are more likely to be following polypharmacy regimens. Population patterns in the U.S. have amplified this trend, with aging baby boomers swelling the patient pool and demanding treatment with medications advertised on television and in print. Fortunately, drug interactions can be prevented with access to current, comprehensive, reliable information, and the Clinical Manual of Drug Interaction Principles for Medical Practice provides just that in a user-friendly format psychiatry clinicians (including residents and nurses) and forensics experts will find indispensable. With this new edition, the book has evolved from "Concise Guide" to "Clinical Manual" and offers the expanded coverage and features healthcare providers need to keep up with this critical field. The book is well organized, with major sections on metabolism; cytochrome P450 enzymes; drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. In the section on P450 enzymes, each chapter addresses what the individual enzyme does and where, its polymorphisms, and drugs that inhibit or induce activity. Each chapter also includes extensive references and study cases to help the reader understand and contextualize the information. A number of additional features enhance the book's scope and utility: The book boasts the very latest information in the area of drug metabolism, transport, and interaction. The chapter on P-glycoprotein (a drug transporter) was expanded from the last edition to include a broader array of transport mechanisms. The highest ethical standard was adhered to in the development of this volume, which was not supported in any way by pharmaceutical makers or distributors. All eight contributors to this excellent resource are experts in the fields they have addressed, and clinicians can trust that the information contained in the Manual reflects the very latest research. This exceptionally practical manual is essential to maintaining the highest standard of care.

Clinical Manual of Drug Interaction Principles for Medical Practice

Clinical Manual of Drug Interaction Principles for Medical Practice
Title Clinical Manual of Drug Interaction Principles for Medical Practice PDF eBook
Author Gary H. Wynn
Publisher American Psychiatric Pub
Pages 0
Release 2009
Genre Medical
ISBN 9781585622962

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Drug interactions have become a significant iatrogenic complication, with as many as 5% of hospitalizations and 7,000 deaths annually attributable to drug-drug interactions in the United States. Drug interactions can be prevented with access to current, comprehensive, reliable information, and the Clinical Manual of Drug Interaction Principles for Medical Practice provides just that in a user-friendly format psychiatry clinicians (including residents and nurses) and forensics experts will find indispensable. with this new edition, the book has evolved from "Concise Guide" to "Clinical Manual

Drug-Drug Interaction Primer

Drug-Drug Interaction Primer
Title Drug-Drug Interaction Primer PDF eBook
Author Neil B. Sandson
Publisher American Psychiatric Pub
Pages 409
Release 2008-05-20
Genre Medical
ISBN 1585626775

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This user-friendly resource offers complete and comprehensive coverage of the difficult challenges posed by drug-drug interactions. Over 170 case vignettes illustrate a variety of interactions (DDIs) to provide an unintimidating -- even entertaining -- approach to understanding these issues. Drug-Drug Interaction Primer builds on the author's earlier work, Drug Interactions Casebook: The Cytochrome P450 System and Beyond, and features updated references throughout and 29 new cases that provide such clinical examples as: a patient diagnosed with schizoaffective disorder transitions from haloperidol to aripiprazole with disastrous results; an AIDS patient's trimethoprim-sulfamethoxazole is replaced with warfarin following atrial fibrillation, resulting in ischemic stroke; and a delusional patient on risperidone is placed on phenytoin following seizures, and delusions return. Previous cases have been revised to enhance clarity. An introduction to core concepts, which includes brief reviews of each enzyme system, brings the reader up to speed on how to think about DDIs and begin to grapple with what might seem like an imposing subject. The vignettes that follow each include a case presentation and an explanation of the mechanism by which the interaction(s) occurred, and each derives from sound clinical evidence -- not merely extrapolations from drug characteristics -- to offer a more realistic understanding of DDIs. Most of the interactions described involve the cytochrome P450 enzyme system; others involve alterations in phase II metabolism and P-glycoprotein functioning, as well as plasma protein displacement effects. The appendices detail most drug-drug interactions between psychotropic agents and contain metabolic pathways and inhibitory and inductive profiles for antidepressants, antipsychotics, and mood stabilizing agents -- as well as tables that detail all known and clinically significant DDIs between pairings of any two agents from these drug classes. An extensive index allows quick reference. Among the book's other features: Reorganization by medical subspecialty -- psychiatry, internal medicine, neurology, surgery/anesthesia, and gynecology, oncology, and dermatology -- better facilitates clinical application. Comprehensive tables detail substrates, inhibitors, and inducers for P450, phase II, and P-glycoprotein. DDIs involving select nonpsychotropic agents such as tobacco, ethinylestradiol, and statins. Exploration of the paradigm of plasma protein binding mediated DDIs in detail, with cases conveniently indexed. These cases bring DDIs alive in a way that drier descriptions cannot, and this volume introduces more original material than will be found in other sources. Drug-Drug Interaction Primer is brimming with material that can be put to immediate use, offering insights that will improve any practitioner's skills.

Massachusetts General Hospital Comprehensive Clinical Psychiatry

Massachusetts General Hospital Comprehensive Clinical Psychiatry
Title Massachusetts General Hospital Comprehensive Clinical Psychiatry PDF eBook
Author Theodore A. Stern
Publisher Elsevier Health Sciences
Pages 2883
Release 2008-04-18
Genre Medical
ISBN 0323076912

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The Massachusetts General Hospital is widely respected as one of the world's premier psychiatric institutions. Now, preeminent authorities from MGH present a reference that is carefully designed to simplify your access to the current clinical knowledge you need! A remarkably user-friendly organization - with abundant boxed summaries, bullet points, case histories, and algorithms - speeds you to the answers you need. In short, this brand-new reference delivers all the authoritative answers you need to overcome any clinical challenge, in a format that's easier to consult than any other source! Peerless, hands-on advice from members of the esteemed MGH Department of Psychiatry helps you put today's best approaches to work for your patients. The book's highly templated format - with abundant boxed overviews, bulleted points, case histories, algorithms, references, and suggested readings - enables you to locate essential information quickly.

Massachusetts General Hospital Handbook of General Hospital Psychiatry E-Book

Massachusetts General Hospital Handbook of General Hospital Psychiatry E-Book
Title Massachusetts General Hospital Handbook of General Hospital Psychiatry E-Book PDF eBook
Author Theodore A. Stern
Publisher Elsevier Health Sciences
Pages 791
Release 2017-08-09
Genre Medical
ISBN 0323496431

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For generations of practitioners, the Massachusetts General Hospital Handbook of General Hospital Psychiatry has been and is the "gold standard" guide to consultation-liaison psychiatry and psychosomatic medicine. The fully updated 7th Edition, by Drs. Theodore A. Stern, Oliver Freudenreich, Felicia A. Smith, Gregory L. Fricchione, and Jerrold F. Rosenbaum, provides an authoritative, easy-to-understand review of the diagnosis, evaluation, and treatment of psychiatric problems experienced by adults and children with medical and surgical conditions. Covers the psychological impact of chronic medical problems and life-threatening diseases, somatic symptom disorders, organ donors and recipients, pain, substance abuse, and polypharmacy, including a thorough review of drug actions and interactions, metabolism, and elimination. - Features DSM-5 updates throughout, as well as case studies in every chapter. - Contains practical tips on how to implement the most current and effective pharmacological therapies as well as cognitive-behavioral approaches. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide
Title Drug Metabolism and Pharmacokinetics Quick Guide PDF eBook
Author Siamak Cyrus Khojasteh
Publisher Springer Science & Business Media
Pages 222
Release 2011-04-07
Genre Medical
ISBN 1441956298

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Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.