Neuroimaging is witnessing a massive increase in the quality and quantity of data being acquired. It is widely recognized that effective interpretation and extraction of information from such data requires quantitative modeling. However, modeling comes in many diverse forms, with different research communities tackling different brain systems, different spatial and temporal scales, and different aspects of brain structure and function. Computational and Network Modeling of Neuroimaging Data provides an authoritative and comprehensive overview of the many diverse modeling approaches that have been fruitfully applied to neuroimaging data. This book gives an accessible foundation to the field of computational and network modeling of neuroimaging data and is suitable for graduate students, academic researchers, and industry practitioners who are interested in adopting or applying model-based approaches in neuroimaging. Provides an authoritative and comprehensive overview of major modeling approaches to neuroimaging data Written by experts, the book's chapters use a common structure to introduce, motivate, and describe a specific modeling approach used in neuroimaging Gives insights into the similarities and differences across different modeling approaches Analyses details of outstanding research challenges in the field

The massive amount of nonstandard high-dimensional brain imaging data being generated is often difficult to analyze using current techniques. This challenge in brain image analysis requires new computational approaches and solutions. But none of the research papers or books in the field describe the quantitative techniques with detailed illustrations of actual imaging data and computer codes. Using MATLAB® and case study data sets, Statistical and Computational Methods in Brain Image Analysis is the first book to explicitly explain how to perform statistical analysis on brain imaging data. The book focuses on methodological issues in analyzing structural brain imaging modalities such as MRI and DTI. Real imaging applications and examples elucidate the concepts and methods. In addition, most of the brain imaging data sets and MATLAB codes are available on the author’s website. By supplying the data and codes, this book enables researchers to start their statistical analyses immediately. Also suitable for graduate students, it provides an understanding of the various statistical and computational methodologies used in the field as well as important and technically challenging topics.

An overview of theoretical and computational approaches to neuroimaging.

Provides an introduction to the neural network modeling of complex cognitive and neuropsychological processes. Over the past few years, computer modeling has become more prevalent in the clinical sciences as an alternative to traditional symbol-processing models. This book provides an introduction to the neural network modeling of complex cognitive and neuropsychological processes. It is intended to make the neural network approach accessible to practicing neuropsychologists, psychologists, neurologists, and psychiatrists. It will also be a useful resource for computer scientists, mathematicians, and interdisciplinary cognitive neuroscientists. The editors (in their introduction) and contributors explain the basic concepts behind modeling and avoid the use of high-level mathematics. The book is divided into four parts. Part I provides an extensive but basic overview of neural network modeling, including its history, present, and future trends. It also includes chapters on attention, memory, and primate studies. Part II discusses neural network models of behavioral states such as alcohol dependence, learned helplessness, depression, and waking and sleeping. Part III presents neural network models of neuropsychological tests such as the Wisconsin Card Sorting Task, the Tower of Hanoi, and the Stroop Test. Finally, part IV describes the application of neural network models to dementia: models of acetycholine and memory, verbal fluency, Parkinsons disease, and Alzheimer's disease. Contributors J. Wesson Ashford, Rajendra D. Badgaiyan, Jean P. Banquet, Yves Burnod, Nelson Butters, John Cardoso, Agnes S. Chan, Jean-Pierre Changeux, Kerry L. Coburn, Jonathan D. Cohen, Laurent Cohen, Jose L. Contreras-Vidal, Antonio R. Damasio, Hanna Damasio, Stanislas Dehaene, Martha J. Farah, Joaquin M. Fuster, Philippe Gaussier, Angelika Gissler, Dylan G. Harwood, Michael E. Hasselmo, J, Allan Hobson, Sam Leven, Daniel S. Levine, Debra L. Long, Roderick K. Mahurin, Raymond L. Ownby, Randolph W. Parks, Michael I. Posner, David P. Salmon, David Servan-Schreiber, Chantal E. Stern, Jeffrey P. Sutton, Lynette J. Tippett, Daniel Tranel, Bradley Wyble

A significant amount of effort in neural modeling is directed towards understanding the representation of information in various parts of the brain, such as cortical maps [6], and the paths along which sensory information is processed. Though the time domain is integral an integral aspect of the functioning of biological systems, it has proven very challenging to incorporate the time domain effectively in neural network models. A promising path that is being explored is to study the importance of synchronization in biological systems. Synchronization plays a critical role in the interactions between neurons in the brain, giving rise to perceptual phenomena, and explaining multiple effects such as visual contour integration, and the separation of superposed inputs. The purpose of this book is to provide a unified view of how the time domain can be effectively employed in neural network models. A first direction to consider is to deploy oscillators that model temporal firing patterns of a neuron or a group of neurons. There is a growing body of research on the use of oscillatory neural networks, and their ability to synchronize under the right conditions. Such networks of synchronizing elements have been shown to be effective in image processing and segmentation tasks, and also in solving the binding problem, which is of great significance in the field of neuroscience. The oscillatory neural models can be employed at multiple scales of abstraction, ranging from individual neurons, to groups of neurons using Wilson-Cowan modeling techniques and eventually to the behavior of entire brain regions as revealed in oscillations observed in EEG recordings. A second interesting direction to consider is to understand the effect of different neural network topologies on their ability to create the desired synchronization. A third direction of interest is the extraction of temporal signaling patterns from brain imaging data such as EEG and fMRI. Hence this Special Session is of emerging interest in the brain sciences, as imaging techniques are able to resolve sufficient temporal detail to provide an insight into how the time domain is deployed in cognitive function. The following broad topics will be covered in the book: Synchronization, phase-locking behavior, image processing, image segmentation, temporal pattern analysis, EEG analysis, fMRI analyis, network topology and synchronizability, cortical interactions involving synchronization, and oscillatory neural networks. This book will benefit readers interested in the topics of computational neuroscience, applying neural network models to understand brain function, extracting temporal information from brain imaging data, and emerging techniques for image segmentation using oscillatory networks

Computational neuroanatomy is an emerging field that utilizes various non-invasive brain imaging modalities, such as MRI and DTI, in quantifying the spatiotemporal dynamics of the human brain structures in both normal and clinical populations. This discipline emerged about twenty years ago and has made substantial progress in the past decade. The main goals of this book are to provide an overview of various mathematical, statistical and computational methodologies used in the field to a wide range of researchers and students, and to address important yet technically challenging topics in further detail.

This coherent mathematical and statistical approach aimed at graduate students incorporates regression and topology as well as graph theory.