Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

The Guest Editors, coming from the Critical Care Medicine Department in the NIH, are the top thought leaders in the area of infections in critical care. Their topic selections in this issue reflect the most clinically relevant and current information. The issue specifically covers the following topics: Catheter-related bloodstream infections: special considerations in diagnosis in the ICU; Sepsis-How does the new definition help clinicians; Therapeutic drug monitoring of antibiotics; High containment pathogen preparation; Multidrug resistant gram negative infections and enterococcus; Strategies to prevent transmission of resistant organisms; Antibiotic Stewardship: What the intensivist should know; C. Difficile infection in the ICU; Immunocompromised critically ill; Rapid diagnostics: The use of procalcitonin; Respiratory viruses in the ICU: Significance of rhino/rsv updates/adenovirus metapneumovirus; Management of invasive fungal disease in the ICU; Inhaled/Nebulized antibiotics. Infectious disease physicians and intensivists will be armed with the information they need to diagnose and treat patients with infections in the ICU.

In this issue of Infectious Disease Clinics of North America, guest editors Drs. Naomi P. O'Grady and Sameer Kadri bring their considerable expertise to the topic of Complex Infectious Diseases Issues in the Intensive Care Unit. Affected immunity of patients with COVID-19 has made management of complex infectious diseases in the intensive care unit more important than ever. This issue provides key updates for managing these complex infectious diseases and includes current clinical information for COVID-19 patients, making this a state-of-the-art collection of review articles for practicing infectious disease physicians. - Contains 13 practice-oriented topics including timing and spectrum of antibiotic treatment for suspected sepsis and septic shock; preparing an ICU for a lethal viral respiratory pandemic; rapid implementation of a system-level ICU pandemic surge staffing amidst quarantined staff and infection control barriers; management of serious SARS-CoV-2 infection with immunotherapies; supportive care in patients with critical COVID-19; and more. - Provides in-depth clinical reviews on complex infectious diseases issues in the ICU, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Infectious Disease Clinics of North America, guest editors Drs. Rachel Bender Ignacio and Rajesh T. Gandhi bring their considerable expertise to the topic of COVID-19 Infection. The evolving virology, wide range of symptoms, long-term health issues, mortality rate, effect on hospitals, and high transmission rate have made COVID-19 one of the worst health crises in recent times. In this issue, top experts in the field address key issues such as diagnostic testing, COVID-19 in pediatrics, post-acute sequelae, infection control, and much more, aiming to arm clinicians with the information they need to combat this deadly infection. - Contains 15 relevant, practice-oriented topics including COVID-19 and global pandemic response, SARS CoV-2 transmission and prevention, COVID-19 Vaccines, COVID-19 treatment, equity and racial/ethnic disparities, and more. - Provides in-depth clinical reviews on COVID-19, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Infectious Disease Clinics of North America, guest editor Dr. Jeanne Marrazzo brings her considerable expertise to the topic of Sexually Transmitted Infections. The CDC approximates that 20% of Americans have experienced a sexually transmitted infection (STI), and the World Health Organization has estimated that over 340 million people live with STIs worldwide every year. In this issue, top experts provide important updates in this area, with goals to provide the relevant clinical information to aid physicians in prevention, diagnosis, and management. - Contains 14 practice-oriented topics including syphilis: a modern resurgence; update in management and prevention of chlamydial infections; non-herpes and non-syphilis causes of genital ulcer disease (including monkeypox, LGV, chancroid); diagnostic advances in sexually transmitted infections; immunizations for sexually transmitted infections; and more. - Provides in-depth clinical reviews on sexually transmitted infections, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

The Guest Editors have compiled a comprehensive issue that addresses the current clinical diagnosis, treatment,and management of infections in children. Top authors in their field have written review articles on the following topics: Update on Varicella Zoster Virus in Children; Emerging Respiratory Viruses in Children; Bronchiolitis in Children; Antimicrobial resistance in pediatrics in Children; New updates in influenza vaccination in Children; Changing epidemiology of CAP in Children; Zika Virus in Children; Ebola Virus in Children; Infections in Children on biologics; New rapid diagnostics in Children; Infections in HSCT Children; Changing epidemiology of H. influenzae infections in Children; Norovirus in Children; PEP in children; Syphilis in Children; Encephalitis in Children; and Malaria in Children. Infectious disease physicians will have the most current and up-to-date best practice information in their field.