Examines the history, current developments, future, and ethical ramifications of cloning, recombinant DNA, and gene therapy.

Duplicated passages of source code - code clones - are a common property of software systems. While clones are beneficial in some situations, their presence causes various problems for software maintenance. Most of these problems are strongly related to change and include, for example, the need to propagate changes across duplicated code fragments and the risk of inconsistent changes to clones that are meant to evolve identically. Hence, we need a sophisticated analysis of clone evolution to better understand, assess, and manage duplication in practice. This thesis introduces Clone Evolution Graphs as a technique to model clone relations and their evolution within the history of a system. We present our incremental algorithm for efficient and automated extraction of Clone Evolution Graphs from a system's history. The approach is shown to scale even for large systems with long histories making it applicable to retroactive analysis ofclone evolution as well as live tracking of clones during software maintenance.We have used Clone Evolution Graphs in several studies to analyze versatile aspects of clone evolution in open-source as well as industrial systems. Our results show that the characteristics of clone evolution are quite different between systems, highlighting the need for a sophisticated technique like Clone Evolution Graphs to track clones and analyze their evolution on a per-system basis. We have also shown that Clone Evolution Graphs are well-suited to analyze the change behavior of individual clones and can be used to identify problematic clones within a system. In general, the results of our studies provide new insights into how clones evolve, how they are changed, and how they are removed.

Animal cloning has developed quickly since the birth of Dolly the sheep. Yet many of the first questions to be raised still need to be answered. What do Dolly and her fellow mouse, cow, pig, goat and monkey clones mean for science? And for society? Why do so many people respond so fearfully to cloning? What are the ethical issues raised by cloning animals, and in the future, humans? How are the makers of public policy coping with the stunning fact that an entire animal can be reconstructed from a single adult cell? And that humans might well be next? The Cloning Source Book addresses all of these questions in a way that is unique in the cloning literature, by grounding what is effectively an interdisciplinary conversation in solid science. In the first section of the book, the key scientists responsible for the early and crucial developments in cloning speak to us directly, and other scientists evaluate and comment on these developments. The second section explores the context of cloning and includes sociological, mythological, and historical perspectives on science, ethics, and policy. The authors also examine the media's treatment of the Dolly story and its aftermath, both in the United States and in Britain. The third section, on ethics, contains a broad range of papers written by some of the major commentators in the field. The fourth section addresses legal and policy issues. It features individual and collective contributions by those who have actually shaped public policy on reproductive cloning, therapeutic cloning, and similarly contentious bioethical issues in the United States, Britain, and the European Union. Animal cloning continues for agricultural and medicinal purposes, the latter in combination with transgenics. Human cloning for therapeutic purposes has recently been made legal in Britain. The goal is to produce an early embryo and then derive stem cells that are immunologically matched to the donor. Two human reproductive cloning projects have been announced, and there are almost certainly others about which we know nothing. Sooner or later a cloned human will be born. Many lessons can be learned from the cloning experience. Most importantly, there needs to be a public conversation about the permissible uses of new and morally murky technologies. Scientists, journalists, ethicists and policy makers all have roles to play, but cutting-edge science is everybody's business. The Cloning Sourcebook provides the tools required for us to participate in shaping our own futures.

This book provides in-depth explorations of genetic cloning, including the history of cloning and the types of artificial cloning for both plants and animals, with fascinating examples. It also explains the possibility of using the gene therapy to cure diseases.

Known world-wide as the standard introductory text to this important and exciting area, the sixth edition of Gene Cloning and DNA Analysis addresses new and growing areas of research whilst retaining the philosophy of the previous editions. Assuming the reader has little prior knowledge of the subject, its importance, the principles of the techniques used and their applications are all carefully laid out, with over 250 clearly presented four-colour illustrations. In addition to a number of informative changes to the text throughout the book, the final four chapters have been significantly updated and extended to reflect the striking advances made in recent years in the applications of gene cloning and DNA analysis in biotechnology. Gene Cloning and DNA Analysis remains an essential introductory text to a wide range of biological sciences students; including genetics and genomics, molecular biology, biochemistry, immunology and applied biology. It is also a perfect introductory text for any professional needing to learn the basics of the subject. All libraries in universities where medical, life and biological sciences are studied and taught should have copies available on their shelves. "... the book content is elegantly illustrated and well organized in clear-cut chapters and subsections... there is a Further Reading section after each chapter that contains several key references... What is extremely useful, almost every reference is furnished with the short but distinct author's remark." –Journal of Heredity, 2007 (on the previous edition)

Theories and results on hyperidentities have been published in various areas of the literature over the last 18 years. Hyperidentities and Clones integrates these into a coherent framework for the first time. The author also includes some applications of hyperidentities to the functional completeness problem in multiple-valued logic and extends the