How did life begin on the early Earth? We know that life today is driven by the universal laws of chemistry and physics. By applying these laws over the past ?fty years, en- mous progress has been made in understanding the molecular mechanisms that are the foundations of the living state. For instance, just a decade ago, the ?rst human genome was published, all three billion base pairs. Using X-ray diffraction data from crystals, we can see how an enzyme molecule or a photosynthetic reaction center steps through its catalytic function. We can even visualize a ribosome, central to all life, translate - netic information into a protein. And we are just beginning to understand how molecular interactions regulate thousands of simultaneous reactions that continuously occur even in the simplest forms of life. New words have appeared that give a sense of this wealth of knowledge: The genome, the proteome, the metabolome, the interactome. But we can’t be too smug. We must avoid the mistake of the physicist who, as the twentieth century began, stated con?dently that we knew all there was to know about physics, that science just needed to clean up a few dusty corners. Then came relativity, quantum theory, the Big Bang, and now dark matter, dark energy and string theory. Similarly in the life sciences, the more we learn, the better we understand how little we really know. There remains a vast landscape to explore, with great questions remaining.

Leading researchers in the area of the origin and evolution of life in the universe contributed to Chemical Evolution: Physics of the Origin and Evolution of Life. This volume provides a review of this interdisciplinary field. In 35 chapters many aspects of the origin of life are discussed by 90 authors, with particular emphasis on the early paleontological record: physical, chemical, biological, and informational aspects of life's origin, instrumentation in exobiology and system exploration; the search for habitable planets and extraterrestrial intelligent radio signals. This book contains the proceedings of the Fourth Trieste Conference on Chemical Evolution that took place in September 1995, in which scientists from a wide geographical distribution joined in a Memorial to Cyril Ponnamperuma, who was a pioneer in the field of chemical evolution, the origin of life, and exobiology, and also initiated the Trieste Conferences on Chemical Evolution and the Origin of Life. This fourth Conference was therefore dedicated to his memory. Audience: Graduate students and researchers in the many areas of basic, earth, and life sciences that contribute to the study of chemical evolution and the origin of life.

The field of planetary biology and chemical evolution draws together experts in astronomy, paleobiology, biochemistry, and space science who work together to understand the evolution of living systems. This field has made exciting discoveries that shed light on how organic compounds came together to form self-replicating molecules-the origin of life. This volume updates that progress and offers recommendations on research programs-including an ambitious effort centered on Mars-to advance the field over the next 10 to 15 years. The book presents a wide range of data and research results on these and other issues: The biogenic elements and their interaction in the interstellar clouds and in solar nebulae. Early planetary environments and the conditions that lead to the origin of life. The evolution of cellular and multicellular life. The search for life outside the solar system. This volume will become required reading for anyone involved in the search for life's beginnings-including exobiologists, geoscientists, planetary scientists, and U.S. space and science policymakers.

Studying the origin of life is one of man’s greatest achievements over the last sixty years. The fields of interest encompassed by this quest are multiple and interdisciplinary: chemistry, physics, biology, biochemistry, mathematics, geology but also statistics, atmospheric science, meteorology, oceanography, and astrophysics. Recent scientific discoveries, such as water on Mars and the existence of super-Earths with atmospheres similar to primordial Earth, have pushed researchers to simulate prebiotic conditions in explaining the abiotic formation of molecules essential to life. This collection of articles offers an overview of recent discoveries in the field of prebiotic chemistry of biomolecules, their formation and selection, and the evolution of complex chemical systems.

The origins of life remains one of the great unsolved mysteries of science. Growing evidence suggests that the first organisms lived deep underground, in environments previously thought to be uninhabitable, and that microbes carried inside rocks have travelled between Earth and Mars. But the question remains: how can life spring into being from non-living chemicals? THE FIFTH MIRACLE reveals the remarkable new theories and discoveries that seem set to transform our understanding of life's role in the unfolding drama of the cosmos.

Here is a fascinating reader-friendly exploration of “the phosphorus enigma.” The volume attempts to answer the questions: How did phosphorus atoms, which are produced inside the inner cores of a handful of huge stars, become concentrated in relatively high proportions in the organisms composing Earth’s biosphere? And how did these phosphate derivatives manage to be included in such a great variety of organic molecules playing essential biochemical roles in all known life forms? Due to the interdisciplinary nature of the topic, the volume is arranged in three sections. The first section introduces the fundamental concepts and notions of physics, chemistry, and biology necessary for the proper understanding of the topics discussed within an astronomical framework. The author then focuses on the role of phosphorus and its compounds within the context of chemical evolution in galaxies, considering its relevance in most essential biochemical functions as well as its peculiar chemistry under different physicochemical conditions. The third section provides an overall perspective on the role of phosphorus and its compounds in current areas of research of solid state physics, materials engineering, nanotechnology or medicine.

Proceedings of the Sixth Trieste Conference on Chemical Evolution, Trieste, Italy, 18-22 September 2000