Cenci [eBook - NC Digital Library]
Title | Cenci [eBook - NC Digital Library] PDF eBook |
Author | Alexandre Dumas père |
Publisher | |
Pages | |
Release | 2010 |
Genre | |
ISBN |
The Theatre of Shelley
Title | The Theatre of Shelley PDF eBook |
Author | Jacqueline Mulhallen |
Publisher | Open Book Publishers |
Pages | 310 |
Release | 2010 |
Genre | Literary Criticism |
ISBN | 1906924309 |
Based on the author's thesis (Ph.D., Anglia Ruskin University).
Academic Writing for Graduate Students
Title | Academic Writing for Graduate Students PDF eBook |
Author | John M. Swales |
Publisher | University of Michigan Press ELT |
Pages | 272 |
Release | 1994 |
Genre | Foreign Language Study |
ISBN |
A Course for Nonnative Speakers of English. Genre-based approach. Includes units such as graphs and commenting on other data and research papers.
Memories of Hawthorne
Title | Memories of Hawthorne PDF eBook |
Author | Rose Hawthorne Lathrop |
Publisher | |
Pages | 510 |
Release | 1897 |
Genre | Literary Criticism |
ISBN |
This is a pre-1923 historical reproduction that was curated for quality. Quality assurance was conducted on each of these books in an attempt to remove books with imperfections introduced by the digitization process. Though we have made best efforts - the books may have occasional errors that do not impede the reading experience. We believe this work is culturally important and have elected to bring the book back into print as part of our continuing commitment to the preservation of printed works worldwide.
Twenty Years in Europe
Title | Twenty Years in Europe PDF eBook |
Author | Samuel Hawkins Marshall Byers |
Publisher | |
Pages | 392 |
Release | 1900 |
Genre | History |
ISBN |
RNA Metabolism in Neurodegenerative Diseases
Title | RNA Metabolism in Neurodegenerative Diseases PDF eBook |
Author | Rita Sattler |
Publisher | Springer |
Pages | 321 |
Release | 2018-06-18 |
Genre | Medical |
ISBN | 331989689X |
It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--‐ coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--‐directional transcription and production of repeat associated non--‐ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.
A Study of Hawthorne
Title | A Study of Hawthorne PDF eBook |
Author | George Parsons Lathrop |
Publisher | |
Pages | 356 |
Release | 1876 |
Genre | Literary Criticism |
ISBN |
This is a pre-1923 historical reproduction that was curated for quality. Quality assurance was conducted on each of these books in an attempt to remove books with imperfections introduced by the digitization process. Though we have made best efforts - the books may have occasional errors that do not impede the reading experience. We believe this work is culturally important and have elected to bring the book back into print as part of our continuing commitment to the preservation of printed works worldwide.