The Cambridge Checkpoint English suite provides a comprehensive, structured resource which covers the Secondary 1 framework for English and seamlessly progresses into the next key stage (covered by our Cambridge IGCSE® First Language English series). This skill-building, write-in Workbook for Stage 9 is designed to support students' learning and provide extra language tasks and reading and writing skills development, including sequencing and cloze exercises.

Stage 8 is endorsed by Cambridge Assessment International Education. Help learners engage with and fully understand topics they are studying with captivating content following the new Cambridge Lower Secondary Science curriculum framework (0893). - Provide activities to increase learners' subject knowledge and develop the skills necessary to think and work scientifically. - Test learners' comprehension of each topic with questions designed to develop deeper thinking skills. - Embed knowledge and increase learners' vocabulary with whole class and smaller group discussion.

Stage 7 is endorsed by Cambridge Assessment International Education. Help learners engage with and fully understand topics they are studying with captivating content following the new Cambridge Lower Secondary Science curriculum framework (0893). - Provide activities to increase learners' subject knowledge and develop the skills necessary to think and work scientifically. - Test learners' comprehension of each topic with questions designed to develop deeper thinking skills. - Embed knowledge and increase learners' vocabulary with whole class and smaller group discussion.

Cambridge Checkpoint Lower Secondary Science Stage 7 is endorsed by Cambridge Assessment International Education. Practise and consolidate knowledge gained from the Student's Book with this, write-in workbook full of corresponding learning activities. - Save time when planning with ready-made homework or extension exercises. -Reinforce student's understanding of key scientific concepts with varied question types, quizzes and the use of ICT. - Challenge learners with extra practice activities to encourage regular self-assessment.

The Cambridge Checkpoint English suite provides a comprehensive, structured resource which covers the Secondary 1 framework for English and seamlessly progresses into the next key stage (covered by our Cambridge IGCSE® First Language English series). A lively, colourful Coursebook for Stage 9, which includes activities to develop Reading and Writing skills, with integrated Speaking and Listening tasks. It contains 12 themed units with a full range of stimulus materials, including a balance of fiction and non-fiction from around the world.

"Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic.