Autoinflammatory diseases are caused by primary dysfunction of the innate immune system, with overlapping symptoms that make diagnosis difficult. This issue of the Dermatologic Clinics offers and introduction to Autoinflammatory Diseases, along with articles on the role of genetics, diagnosing these diseases, managing them from a dermatologic, pediatric, and rheumatologic standpoint and the various treatment options available.

Autoinflammatory diseases are caused by primary dysfunction of the innate immune system, with overlapping symptoms that make diagnosis difficult. This issue of the Dermatologic Clinics offers and introduction to Autoinflammatory Diseases, along with articles on the role of genetics, diagnosing these diseases, managing them from a dermatologic, pediatric, and rheumatologic standpoint and the various treatment options available.

In the first volume of this two part issue devoted to Autoimmune Blistering Diseases (AIBD), diagnosis and clinical features of these diseases are covered by an internationally recognized group of authors. Topics include Pemphigus Vulgaris, Pemphigus Foliaceus, Linear IgA Bullous Disease, and Hair and Nail Loss in AIBD.

This issue of Dermatologic Clinics, guest edited by Dr. John J. DiGiovanna, is devoted to Skin Science Contributions in Clinical Dermatology. Articles in this issue include Mosaic mTORopathies; CYLD: Cause and Therapeutic Target for Cylindromas; Current Status of Dedicator of Cytokinesis (DOCK), DOCK8, DOCK2; IL-22 relation to Tumor Aggression and Role of Cyclosporine; Dual Lineage of Dermal Fibroblasts and Potential for Scar Correction, Reformation of Adnexal Structures; Inflammasome Instigated Autoinflammatory Disorders; Pigment Cell Biology; Antimicrobial Peptides; and Choosing Friend or Foe? Commensal-specific tolerance.

Part II of Dr. Murrell’s issue devoted to Autoimmune Blistering Diseases focuses on the management of these conditions along with drug treatment, complications, and the treatment of AIBD around the world. Articles include corticosteroid use in AIBD, AIBD management in pregnancy, prevention of opportunistic infections, and therapeutic approaches to patients with mucous membrane pemphigoid, as well as AIBD management in France, Iran, the United States and other countries.

This most common of all dermatologic conditions seen by dermatologists. What are new developments. What do dermatologists need to best treat their patients? In this issue of Dermatologic Clinics, expert practitioners and academics, Dr. James Del Rosso and Dr. Joshua Zeichner lead distinguished clinicians in presenting such topics as: How the Internet and Social Media Have Changed the Management of Acne; Evaluation of Acne Scars: How to Assess Them and What To Tell The Patient; Pathophysiology of Acne; The Role of Skin Care in the Management of Acne Vulgaris; Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris; Use of Oral Contraceptives for Acne Vulgaris: Practical Considerations in Real World Practice; Use of Antibiotics in Acne: Achieving Optimal Outcomes While Maintaining Antibiotic Stewardship; Status Report on Oral Isotretinoin: Has Anything Changed That Is Relevant to Clinicians?; Safety Considerations and Monitoring in Patients Treated with Systemic Medications for Acne; Evaluation and Management of Refractory Acne Vulgaris in Adolescent and Adult Men; Physical Modalities in the Management of Acne; 12. Cases of "Acne" That Turned Out To Not Be Acne.

Part II of Dr. Murrell's issue devoted to Autoimmune Blistering Diseases focuses on the management of these conditions along with drug treatment, complications, and the treatment of AIBD around the world. Articles include corticosteroid use in AIBD, AIBD management in pregnancy, prevention of opportunistic infections, and therapeutic approaches to patients with mucous membrane pemphigoid, as well as AIBD management in France, Iran, the United States and other countries.