This issue of Cardiology Clinics, guest edited by Drs. Marie-Annick Clavel and Philippe Pibarot, focuses on Aortic Valve Disease. Articles in this issue include, but are not limited to: Pathophysiology of Aortic Stenosis and future perspectives for medical therapy, Assessment of Aortic Stenosis Severity, Assessment of Cardiac Damage in Aortic stenosis, Aortic Stenosis with Other Concomitant Valvular Disease (AR, MR, TR), Biomarker in Aortic Stenosis, Aortic stenosis guidelines: evidence gaps and changing concepts, Heart Valve Clinics and Heart Valve Centers, Frailty and Multi-Comorbidities in Aortic Stenosis, Procedures and Outcomes of Surgical Aortic Valve Replacement, Patient selection and Work-up for Transcatheter Aortic Valve Replacement, Procedures and Outcomes of Transcatheter Aortic Valve Replacement, Sex differences in the Pathophysiology, Diagnosis, and Management of Aortic Stenosis, Implications of Aortic stenosis in Pregnancy and Non-Cardiac Surgery.

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Challenges for the treatment of valvular heart disease include the growing need for effective yet less invasive interventions and therapies to treat these progressive conditions. With the development of potential new treatments, it is crucial for cardiac physicians to be well informed on the pathophysiology, assessment, treatment options and their outcomes of valvular diseases. Written by a highly experienced and internationally recognized group of cardiologists, cardiac surgeons, and researchers, Valvular Heart Disease offers insights into the widely varying hemodynamic effects and clinical course of heart valve conditions, as well as the contemporary management of these conditions. Offering a broad perspective on these diseases, Valvular Heart Disease expands on the recent guidelines developed by the major heart societies in the United State and Europe.

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

This issue of Cardiology Clinics will cover Adult Congenital Heart Disease. Curated by Dr. Curt J. Daniels, this issue will explore topics in the field that are relevant for practicing clinicians. This issue is one of four selected each year by the series editorial board: Jamil A. Aboulhosn, David M. Shavelle, Terrence D. Welch, and Audrey H. Wu. The volume will include articles on: ACHD Epidemiology and Work Force, Access and Delivery of ACHD Care, Atrial Septal Defect, Bicuspid Aortic Valve and ACHD Aortopathy, Coarctation of the Aorta, Ebstein Anomaly, Tetralogy of Fallot, Single Ventricle and Fontan Physiology, ACHD Transcatheter Therapy, ACHD Electrophysiology ̧ ACHD Cardiothoracic Surgery, Psychosocial Aspects of ACHD, Congenital Heart Disease and Pulmonary Hypertension, ACHD Heart Failure, and Mechanical Support and Transplant.

Among the most recently developed procedures for treating heart disease in a minimally invasive way are the techniques for percutaneous treatment of valvular heart disease. These are important advances because the only alternative is open heart surgery, which is not an option for many high-risk patients. This issue provides a detailed description of several percutaneous procedures, including trans-catheter aortic valve implantation.

This issue of Cardiology Clinics, curated by Dr. Melinda Davis and Dr. Kathryn Lindley, will explore topics related to Pregnancy and Heart Disease. This issue is one of four selected each year by the series editorial board: Jamil A. Aboulhosn, David M. Shavelle, Terrence D. Welch, and Audrey H. Wu. Topics in this volume include, but are not limited to, Cardiovascular Contribution to Maternal Mortality, Risk stratification and The Pregnancy Heart Team, Cardiovascular Testing in Pregnant Women, Obstetric Considerations and Delivery Planning, Adult Congenital Heart Disease, Aortopathies and Vascular Disease, Arrhythmias, Hypertensive Disorders of Pregnancy, Ischemic Heart Disease, Pulmonary Arterial Hypertension, Peripartum Cardiomyopathy ̧ Hypertrophic Cardiomyopathy, Valvular Heart Disease, Medication Safety during Pregnancy, and Delivering Coordinated Care from Preconception through Postpartum.