Life as an angel can be hell! The angel Alexiel loved God, but she rebelled against Heaven when she saw how disgracefully the other angels were behaving. She was finally captured, and as punishment sent to Earth to live an endless series of tragic lives. She now inhabits the body of Setsuna Mudo, a troubled teen in love with his sister Sara. Setsuna's misery mirrors the chaos among the angels, and their combined passions threaten to destroy both Heaven and Earth. Why is Setsuna so mixed up? Despite his attempts to be noble, he'll fight anyone anytime; he ignores all authority; and he harbors feelings for his sister that can only be described as "incestuous." Why is he such a mess? The reason may be found with two demons from the underworld and their enemy, an insane angel who is distributing an insidious computer game called Angel Santuary.

The most insane creatures in the nine planes of heaven and nine planes of hell are all telling messed-up teenager, Setsuna that he is the reincarnation of an angel. That wouldn't be so bad except that some of these beings are trying to kill him, and others want him to lead them in a revolt against God! All Setsuna wants to do is keep a sister he loves away from the dangerous creatures who are trying to harm her. Unfortunately some of the worst harm can come from Setsuna's love, which threatens to bloom into full-blown incest! How can Setsuna protect his sister from himself?! -- VIZ Media

Setsuna and his team have broken into prison to rescue their ally Zaphikel. But they are shocked to find out that they're too late--Zaphikel's wings have already been cut off. Without their protection, he is infected with disease, and is on his way to becoming a flesh-devouring ghoul. Meanwhile, the evil angel Rosiel chairs a meeting of the leaders of heaven. He announces that he is one step ahead of Setsuna and the rebels, as he knows where they plan to escape to after the prison break. So when Setsuna's team arrives at their destination, they'll find a rather nasty surprise waiting for them! -- VIZ Media

Setsuna is ready to storm the gates of Heaven and rescue his sister Sara, but things are not that simple. He accepts help from the enigmatic angel Zaphikel, but finds a difficult price attached--Zaphikel is looking for someone to lead an army against the Angels and he wants Setsuna to head the charge. Sara has her own plans for escape, but they also come with a price. And just when Setsuna thinks he knows everything about Angels, he discovers a terrifying new secret. Tensions are rising and Heaven is on the verge of war. Will Setsuna and Sara be reunited just in time to watch two armies of Angels tear their world apart? -- VIZ Media

In this final volume, Setsuna and the high angels have entered the Tower of Etenamenki and approached the throne of God. There they find all secrets revealed--the reason for the creation of angels and demons, the origins of the two wars of Heaven and Hell, and the real whereabouts of Adam Kadamon. Meanwhile, the battle outside the Tower rages on. Sara, still possessed by the Angel of Destruction Sandalphon, is intent on destroying the Tower and all inside, as a first step in the destruction of all creation. In the face of this onslaught, can Setsuna prevent the Apocalypse and restore the balance of life on Earth? -- VIZ Media

With just seven days to find his beloved sister Sara in the afterlife, Setsuna goes to hell, only to find himself sitting in judgment of the very angel who condemned his soul to life after life of suffering. But the only way out of the pit is through it, and how much time can Setsuna waste on revenge? Meanwhile Heaven is falling apart as assassins move in to murder God's highest ranking angels! Will there be a universe left when-and if-Setsuna gets out? -- VIZ Media

As the pieces fall into place, High Angel Rosiel's master plan becomes clear. With Lucifer under his control, he intends to enter Atziluth, the highest plane of Heaven, through the Gate of the Grand Cross and take control of the Tablet of Heaven, an object that can grant all wishes. Aware of Rosiel's plan, Setsuna and the other angels race to the Gate to stop Rosiel from bringing about the destruction of the world. But the closer they get the more they see that Lucifer may have his own reasons for entering the Gate. -- VIZ Media