The basic principles of scientific research from the great French physiologist whose contributions in the 19th century included the discovery of vasomotor nerves; nature of curare and other poisons in human body; more.

The French physiologist Claude Bernard was responisble for investigating the chemical phenomena of digestion. This text reproduces his research into experimental medicine. A new introduction looks at his impact on the world of medicine.

First English translation of the classical work on the principles of physiological investigation in life sciences.

This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues. Chapters address specific types of studies such as clinical experiments in small numbers of patients, pharmacokinetics and pharmacodynamics, and gene therapy and pharmacogenomic studies. A major section describes modern techniques of translational clinical research, including gene expression, identifying mutations and polymorphisms, cloning, transcriptional profiling, proteomics, cell and tissue imaging, tissue banking, evaluating substrate metabolism, and in vivo imaging.

Many surgical revolutions distinguish the history and evolution of surgery. Some are small, others more dominant, but each revolution improves the art and science of surgery. Surgical revolutionaries are indispensable in the conception and completion of any surgical revolution, initiating scientific and technological advances that propel surgical practice forward. Surgical revolutionaries can come in the guises of Lister (antisepsis), Halsted (surgical residency and safe surgery), Cushing (safe brain surgery), Wangensteen (gastrointestinal physiological surgery), Blalock (relief of cyanotic heart disease), Lillehei (open heart surgery), and many others. With the hindsight of history, we can recognize patterns of progress, evaluate means of advancing new ideas, and solidify details of innovative behavior that could lead to new surgical revolutions. This volume examines the following vital questions in detail: What is a surgical revolution and how do we recognize one? Are surgical revolutionaries different? Is there a way to educate new surgical revolutionaries? Can history provide enduring examples of surgical revolutions? Are there different kinds of surgical revolutions? What characterizes a surgical revolution in the context of science and technology? What surgical revolutions are on the horizon?

Social problems in many domains, including health, education, social relationships, and the workplace, have their origins in human behavior. The documented links between behavior and social problems have compelled governments and organizations to prioritize and mobilize efforts to develop effective, evidence-based means to promote adaptive behavior change. In recognition of this impetus, The Handbook of Behavior Change provides comprehensive coverage of contemporary theory, research, and practice on behavior change. It summarizes current evidence-based approaches to behavior change in chapters authored by leading theorists, researchers, and practitioners from multiple disciplines, including psychology, sociology, behavioral science, economics, philosophy, and implementation science. It is the go-to resource for researchers, students, practitioners, and policy makers looking for current knowledge on behavior change and guidance on how to develop effective interventions to change behavior.

What does it mean to live in a time when medical science can not only cure the human body but also reshape it? How should we as individuals and as a society respond to new drugs and genetic technologies? Sheila and David Rothman address these questions with a singular blend of history and analysis, taking us behind the scenes to explain how scientific research, medical practice, drug company policies, and a quest for peak performance combine to exaggerate potential benefits and minimize risks. They present a fascinating and factual story from the rise of estrogen and testosterone use in the 1920s and 1930s to the frenzy around liposuction and growth hormone to the latest research into the genetics of aging. The Rothmans reveal what happens when physicians view patients’ unhappiness and dissatisfaction with their bodies—short stature, thunder thighs, aging—as though they were diseases to be treated. The Pursuit of Perfection takes us from the early days of endocrinology (the belief that you are your hormones) to today’s frontier of genetic enhancements (the idea that you are your genes). It lays bare the always complicated and sometimes compromised positions of science, medicine, and commerce. This is the book to read before signing on for the latest medical fix.