Transforming the energy system is at the core of the dedicated sustainable development goal on energy within the new United Nations development agenda. This publication explores the possible contribution of nuclear energy to addressing the issues of sustainable development through a large selection of indicators. It reviews the characteristics of nuclear power in comparison with alternative sources of electricity supply, according to economic, social and environmental pillars of sustainability. The findings summarized in this publication will help the reader to consider, or reconsider, the contribution that can be made by the development and operation of nuclear power plants in contributing to more sustainable energy systems.