An Automated Pipeline for Phenotyping Embryonic Lethal Mice Using 3D Imaging
Title | An Automated Pipeline for Phenotyping Embryonic Lethal Mice Using 3D Imaging PDF eBook |
Author | Michael David Wong |
Publisher | |
Pages | |
Release | 2015 |
Genre | |
ISBN |
Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine
Title | Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine PDF eBook |
Author | National Academies of Sciences, Engineering, and Medicine |
Publisher | National Academies Press |
Pages | 139 |
Release | 2018-06-29 |
Genre | Science |
ISBN | 0309471168 |
Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.
Small Animal Imaging
Title | Small Animal Imaging PDF eBook |
Author | Fabian Kiessling |
Publisher | Springer |
Pages | 871 |
Release | 2017-05-22 |
Genre | Medical |
ISBN | 3319422022 |
This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Mouse Genetics
Title | Mouse Genetics PDF eBook |
Author | Shree Ram Singh |
Publisher | Humana |
Pages | 0 |
Release | 2016-09-17 |
Genre | Medical |
ISBN | 9781493945672 |
Mouse Genetics: Methods and Protocols provide selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages and modeling human diseases. Composed in the highly successful Methods in Molecular Biology series format, each chapter contains a brief introduction, a list of necessary materials, systematic, readily reproducible methods and a notes section, which shares tips on troubleshooting in order to avoid known pitfalls. Comprehensive and authoritative, Mouse Genetics: Methods and Protocols promises to deliver fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students and postdoctoral fellows working in the various disciplines of mouse biology and modeling human disease.
The Zebrafish: Disease Models and Chemical Screens
Title | The Zebrafish: Disease Models and Chemical Screens PDF eBook |
Author | |
Publisher | Academic Press |
Pages | 591 |
Release | 2011-09-09 |
Genre | Technology & Engineering |
ISBN | 0123813212 |
This volume of Methods in Cell Biology is the 3e, and provides comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 2004. This new volume on Disease Models and Chemical Screens, covers two rapidly emerging and compelling applications of the zebrafish. Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls This volume concentrates on Disease Models and Chemical Screens
Preparing for Future Products of Biotechnology
Title | Preparing for Future Products of Biotechnology PDF eBook |
Author | National Academies of Sciences, Engineering, and Medicine |
Publisher | National Academies Press |
Pages | 231 |
Release | 2017-07-28 |
Genre | Science |
ISBN | 0309452058 |
Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.
Genes in Conflict
Title | Genes in Conflict PDF eBook |
Author | Austin BURT |
Publisher | Harvard University Press |
Pages | 613 |
Release | 2009-06-30 |
Genre | Science |
ISBN | 0674029119 |
Covering all species from yeast to humans, this is the first book to tell the story of selfish genetic elements that act narrowly to advance their own replication at the expense of the larger organism.