It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

This book constitutes the refereed proceedings of the 11th Annual European Symposium on Algorithms, ESA 2003, held in Budapest, Hungary, in September 2003. The 66 revised full papers presented were carefully reviewed and selected from 165 submissions. The scope of the papers spans the entire range of algorithmics from design and mathematical analysis issues to real-world applications, engineering, and experimental analysis of algorithms.

This book constitutes the refereed proceedings of the 16th Annual European Symposium on Algorithms, ESA 2008, held in Karlsruhe, Germany, in September 2008 in the context of the combined conference ALGO 2008. The 67 revised full papers presented together with 2 invited lectures were carefully reviewed and selected: 51 papers out of 147 submissions for the design and analysis track and 16 out of 53 submissions in the engineering and applications track. The papers address all current subjects in algorithmics reaching from design and analysis issues of algorithms over to real-world applications and engineering of algorithms in various fields. Special focus is given to mathematical programming and operations research, including combinatorial optimization, integer programming, polyhedral combinatorics and network optimization.

This book constitutes the refereed proceedings of the 15th Annual European Symposium on Algorithms, ESA 2007, held in Eilat, Israel, in October 2007 in the context of the combined conference ALGO 2007. The 63 revised full papers presented together with abstracts of three invited lectures address all current subjects in algorithmics reaching from design and analysis issues of algorithms over to real-world applications and engineering of algorithms in various fields.

This book constitutes the proceedings of the 18th Annual European Symposium on Algorithms, held in Liverpool, UK in September 2010.

This book constitutes the refereed proceedings of the 21st Annual European Symposium on Algorithms, ESA 2013, held in Sophia Antipolis, France, in September 2013 in the context of the combined conference ALGO 2013. The 69 revised full papers presented were carefully reviewed and selected from 303 initial submissions: 53 out of 229 in track "Design and Analysis" and 16 out of 74 in track "Engineering and Applications". The papers in this book present original research in all areas of algorithmic research, including but not limited to: algorithm engineering; algorithmic aspects of networks; algorithmic game theory; approximation algorithms; computational biology; computational finance; computational geometry; combinatorial optimization; data compression; data structures; databases and information retrieval; distributed and parallel computing; graph algorithms; hierarchical memories; heuristics and meta-heuristics; mathematical programming; mobile computing; on-line algorithms; parameterized complexity; pattern matching; quantum computing; randomized algorithms; scheduling and resource allocation problems; streaming algorithms.

This volume contains the 74 contributed papers and abstracts of 4 of the 5 invited talks presented at the 10th Annual European Symposium on Algorithms (ESA 2002), held at the University of Rome “La Sapienza”, Rome, Italy, 17-21 September, 2002. For the ?rst time, ESA had two tracks, with separate program committees, which dealt respectively with: – the design and mathematical analysis of algorithms (the “Design and An- ysis” track); – real-world applications, engineering and experimental analysis of algorithms (the “Engineering and Applications” track). Previous ESAs were held in Bad Honnef, Germany (1993); Utrecht, The Neth- lands (1994); Corfu, Greece (1995); Barcelona, Spain (1996); Graz, Austria (1997); Venice, Italy (1998); Prague, Czech Republic (1999); Saarbruc ̈ ken, Ger- ? many (2000), and Arhus, Denmark (2001). The predecessor to the Engineering and Applications track of ESA was the Annual Workshop on Algorithm En- neering (WAE). Previous WAEs were held in Venice, Italy (1997), Saarbruc ̈ ken, ? Germany (1998), London, UK (1999), Saarbru ̈cken, Germany (2000), and Arhus, Denmark (2001). The proceedings of the previous ESAs were published as Springer LNCS volumes 726, 855, 979, 1284, 1461, 1643, 1879, and 2161. The proceedings of WAEs from 1999 onwards were published as Springer LNCS volumes 1668, 1982, and 2161.