This book offers a broad-ranging assessment of current efforts of the molecular, cellular, hormonal, nutritional and lifestyle strategies being tested and applied by biogerontologists in the search for effective means of intervention, prevention and treatment of age-related diseases, and for achieving healthy old age. Employing a semi-academic style, the book presents data from experimental systems, while focusing primarily on their applications to humans in the prevention and treatment of age-related impairments.

Mr. Lipton’s book is the first complete and unbiased survey of the beat generation and its role in our society. Here are the intimate facts about these people and their attitudes toward sex, dope, jazz, art, religion, parents, landlords, employers, politicians, draft boards, the law and, most important, toward the “square”. The author presents a picture of their way of life, their individual backgrounds, the language they have appropriated, in terms made clear for the first time to those of us who have been confused and puzzled about them. He also provides a balanced discussion of their literature, art and music, of what they produce and fail to produce in the arts they practice.—Print Ed.

In Polyadenylation: Methods and Protocols, expert researchers in the field detail many of the protocols which are now commonly used to study polyadenylation. Focusing on recent advances in the fast-moving polyadenylation filed, that has recently been recognized as a key contributor to the complexity of mammalian gene expression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.

"This is the colorful and dramatic biography of two of America's most controversial entrepreneurs: Moses Louis Annenberg, 'the racing wire king, ' who built his fortune in racketeering, invested it in publishing, and lost much of it in the biggest tax evasion case in United States history; and his son, Walter, launcher of TV Guide and Seventeen magazines and former ambassador to Great Britain."--Jacket.

Provides structural engineers with the knowledge and practical tools needed to perform structural designs for wind that incorporate major technological, conceptual, analytical and computational advances achieved in the last two decades. With clear explanations and documentation of the concepts, methods, algorithms, and software available for accounting for wind loads in structural design, it also describes the wind engineer's contributions in sufficient detail that they can be effectively scrutinized by the structural engineer in charge of the design. Wind Effects on Structures: Modern Structural Design for Wind, 4th Edition is organized in four sections. The first covers atmospheric flows, extreme wind speeds, and bluff body aerodynamics. The second examines the design of buildings, and includes chapters on aerodynamic loads; dynamic and effective wind-induced loads; wind effects with specified MRIs; low-rise buildings; tall buildings; and more. The third part is devoted to aeroelastic effects, and covers both fundamentals and applications. The last part considers other structures and special topics such as trussed frameworks; offshore structures; and tornado effects. Offering readers the knowledge and practical tools needed to develop structural designs for wind loadings, this book: Points out significant limitations in the design of buildings based on such techniques as the high-frequency force balance Discusses powerful algorithms, tools, and software needed for the effective design for wind, and provides numerous examples of application Discusses techniques applicable to structures other than buildings, including stacks and suspended-span bridges Features several appendices on Elements of Probability and Statistics; Peaks-over-Threshold Poisson-Process Procedure for Estimating Peaks; estimates of the WTC Towers’ Response to Wind and their shortcomings; and more Wind Effects on Structures: Modern Structural Design for Wind, 4th Edition is an excellent text for structural engineers, wind engineers, and structural engineering students and faculty.

xxxxx proposes a radical, new space for artistic exploration, with essential contributions from a diverse range of artists, theorists, and scientists. Combining intense background material, code listings, screenshots, new translation, [the] xxxxx [reader] functions as both guide and manifesto for a thought movement which is radically opposed to entropic contemporary economies. xxxxx traces a clear line across eccentric and wide ranging texts under the rubric of life coding which can well be contrasted with the death drive of cynical economy with roots in rationalism and enlightenment thought. Such philosophy, world as machine, informs its own deadly flipside embedded within language and technology. xxxxx totally unpicks this hiroshimic engraving, offering an dandyish alternative by way of deep examination of software and substance. Life coding is primarily active, subsuming deprecated psychogeography in favour of acute wonderland technology, wary of any assumed transparency. Texts such as Endonomadology, a text from celebrated biochemist and chaos theory pioneer Otto E. Roessler, who features heavily throughout this intense volume, make plain the sadistic nature and active legacy of rationalist thought. At the same time, through the science of endophysics, a physics from the inside elaborated here, a delicate theory of the world as interface is proposed. xxxxx is very much concerned with the joyful elaboration of a new real; software-led propositions which are active and constructive in eviscerating contemporary economic culture. xxxxx embeds Perl Routines to Manipulate London, by way of software artist and Mongrel Graham Harwood, a Universal Dovetailer in the Lisp language from AI researcher Bruno Marchal rewriting the universe as code, and self explanatory Pornographic Coding from plagiarist and author Stewart Home and code art guru Florian Cramer. Software is treated as magical, electromystical, contrasting with the tedious GUI desktop applications and user-led drudgery expressed within a vast ghost-authored literature which merely serves to rehearse again and again the demands of industry and economy. Key texts, which well explain the magic and sheer art of programming for the absolute beginner are published here. Software subjugation is made plain within the very title of media theorist Friedrich Kittler's essay Protected Mode, published in this volume. Media, technology and destruction are further elaborated across this work in texts such as War.pl, Media and Drugs in Pynchon's Second World War, again from Kittler, and Simon Ford's elegant take on J.G Ballard's crashed cars exhibition of 1970, A Psychopathic Hymn. Software and its expansion stand in obvious relation to language. Attacking transparency means examining the prison cell or virus of language; life coding as William Burrough's cutup. And perhaps the most substantial and thorough-going examination is put forward by daring Vienna actionist Oswald Wiener in his Notes on the Concept of the Bio-adapter which has been thankfully unearthed here. Equally, Olga Goriunova's extensive examination of a new Russian literary trend, the online male literature of udaff.com provides both a reexamination of culture and language, and an example of the diversity of xxxxx; a diversity well reflected in background texts ranging across subjects such as Leibniz' monadology, the ur-crash of supreme flaneur Thomas de Quincey and several rewritings of the forensic model of Jack the Ripper thanks to Stewart Home and Martin Howse. xxxxx liberates software from the machinic, and questions the transparency of language, proposing a new world view, a sheer electromysticism which is well explained with reference to the works of Thomas Pynchon in Friedrich Kittler's essay, translated for the first time into English, which closes xxxxx. Further contributors include Hal Abelson, Leif Elggren, Jonathan Kemp, Aymeric Mansoux, and socialfiction.org.