Note to Readers: Publisher does not guarantee quality or access to any included digital components if book is purchased through a third-party seller. Specifically designed for future healthcare providers who will diagnose, manage, and prescribe This advanced physiology and pathophysiology text is designed to address the specific learning needs of future nurse practitioners, physician assistants, and other advanced healthcare providers caring for patients across the lifespan. Focusing on practical applications of physiology, it facilitates in-depth understanding of important pathophysiological concepts as they relate to major disorders commonly seen in clinical practice and includes comprehensive pediatric and geriatric considerations. This knowledge is crucial to providing the foundation required to be an informed and confident clinical decision maker. The author team includes experienced clinicians and educators: nurses and nurse practitioners, physician assistants, doctors of pharmacy, physicians, and basic scientists. This collaboration has produced a text that carefully details and richly illustrates the cellular structure and function of each organ system and mechanisms of associated major clinical disorders. Uniquely interweaving aspects of organ function during healthy states with disease-associated changes, the text emphasizes and extends the basic science foundation to practical clinical applications. The text promotes a deep understanding of cellular function in health and disease that provides the bedrock knowledge required to master pharmacology for prescriptive practice. Equally important, the solid foundation of applied pathophysiological mechanisms offered in this text prepares the student clinician to care for patients with a broad variety of disorders. This resource not only provides a deep dive into pathophysiology, but it also examines why patients often present with particular symptoms, the rationale for ordering specific diagnostic tests and interpretation of results, and common management strategies that proceed from the underlying pathophysiology. Key Features: Designed explicitly to build a foundation for pharmacology and clinical courses that lead to successful clinical practice and prescribing Includes comprehensive lifespan considerations with key insights from specialists in pediatric and geriatric pathophysiology Provides a complete chapter on the basic principles of genetics and genomics with coverage of genetic variations, assessment, and genomics woven throughout the book Integrates thought questions and case studies to promote discussion and synthesis of information Offers a unique Bridge to Clinical Practice in each chapter to translate science to patient care Includes more than 500 images to illustrate complex scientific concepts Summarizes the contents succinctly with handy key points at the end of each chapter Provides access to the fully searchable ebook, including student ancillaries on Springer Publishing ConnectTM

Edited by physiology instructors who are also active clinicians, Integrated Physiology and Pathophysiology is a one-stop guide to key information you need for early clinical and medical training and practice. This unique, integrated textbook unites these two essential disciplines and focuses on the most relevant aspects for clinical application. A concise, review-like format, tables and diagrams, spaced repetition for effective learning, and self-assessment features help you gain and retain a firm understanding of basic physiology and pathophysiology. Integrated Physiology and Pathophysiology works equally well as a great starting point in your studies and as a review for boards. - Shares the knowledge and expertise of an outstanding editorial team consisting of two practicing clinicians who also teach physiology and pathophysiology at Harvard Medical School, plus a top Harvard medical student. - Provides an integrated approach to physiology and pathophysiology in a concise, bulleted format. Chapters are short and focus on clinically relevant, foundational concepts in clear, simple language. - Employs focused repetition of key points, helping you quickly recall core concepts such as pressure-flow-resistance relationships, ion gradients and action potentials, and mass balance. You'll revisit these concepts in a variety of meaningful clinical contexts in different chapters; this "spaced learning" method of reinforcement promotes deeper and more flexible understanding and application. - Includes Fast Facts boxes that emphasize take-home messages or definitions. - Contains Integration boxes that link physiology and pathophysiology to pharmacology, genetics, and other related sciences. - Presents clinical cases and with signs and symptoms, history, and laboratory data that bring pathophysiology to life. - Features end-of-chapter board-type questions, complete with clear explanations of the answers, to help prepare you for standardized exams. - Evolve Instructor site with an image and test bank as well as PowerPoint slides is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.

Written by international experts in physiology, exercise physiology, and research, ACSM's Advanced Exercise Physiology gives students an advanced level of understanding of exercise physiology. It emphasizes the acute and chronic effects of exercise on various physiological systems in adults and the integrative nature of these physiological responses. Chapters detail how different body systems respond to exercise. Systems include nervous, skeletal, muscular, respiratory, cardiovascular, gastrointestinal, metabolic, endocrine, immune, renal, and hematopoietic systems. Additional chapters explain how these responses are altered by heat, cold, hypoxia, microgravity, bed rest, and hyperbaria. Milestones of Discovery pages describe classic or memorable experiments in exercise physiology.

Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverage includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role of glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides

Expanded, updated, and now in full color throughout, this Fourth Edition presents vital pathophysiology information in an easy-to-understand, easy-to-remember, entertaining, and practical manner. Chapters cover cancer, infection, immune disorders, genetics, blood, and disorders of each body system, highlighting pathophysiologic processes, signs and symptoms, diagnostic test findings, and current treatments. Illustrations, memory joggers, and other special features help readers understand and remember key points. This edition's expanded cancer chapter covers more types of cancer. The Practice Makes Perfect self-test includes more NCLEX®-style questions, with rationales for correct and incorrect answers. A companion website on thePoint will offer additional information, illustrations, memory joggers, and study cards.

CD on Differentail Diagnosis, shows the interpretation of common lab tests and patient symptoms and signs, also facilitates searching several reference services for additional information.